Evidence map›Paper›PMID 33245320›Full record

ReviewBiochemical Society transactions2020

Post-transcriptional control of mitochondrial protein composition in changing environmental conditions.

Tatsuhisa Tsuboi, Jordan Leff, Brian M Zid

Abstract readReview
In one paragraph

Review in Biochemical Society transactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Heme sensing and trafficking in fungi.Fungal biology reviews · 2023
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tatsuhisa TsuboiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92023-0358, U.S.A.
Jordan LeffDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92023-0358, U.S.A.
Brian M ZidDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92023-0358, U.S.A.

Funding

Undergraduate Summer Research Supplement to R35R35GM128798 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZID, BRIAN MATTHEW · 2018 to 2023
$2.3M
NIGMS NIH HHS R35 GM128798
6 · The paper itself

Abstract

In fluctuating environmental conditions, organisms must modulate their bioenergetic production in order to maintain cellular homeostasis for optimal fitness. Mitochondria are hubs for metabolite and energy generation. Mitochondria are also highly dynamic in their function: modulating their composition, size, density, and the network-like architecture in relation to the metabolic demands of the cell. Here, we review the recent research on the post-transcriptional regulation of mitochondrial composition focusing on mRNA localization, mRNA translation, protein import, and the role that dynamic mitochondrial structure may have on these gene expression processes. As mitochondrial structure and function has been shown to be very important for age-related processes, including cancer, metabolic disorders, and neurodegeneration, understanding how mitochondrial composition can be affected in fluctuating conditions can lead to new therapeutic directions to pursue.

Indexed as

Gene Expression RegulationProtein TransportAnimalsCell CycleCell RespirationCricetinaeEnvironmentFermentationFungal ProteinsGenes, FungalHeLa CellsHomeostasisHumansMitochondriaMitochondrial ProteinsMyocardiumFungal ProteinsMitochondrial ProteinsRNA, Messengermitochondriamitochondrial morphologymRNAmRNA localizationmRNA translationprotein import

Identifiers

PMID33245320
PMCPMC8108647

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.