Evidence map›Paper›PMID 33245317›Full record

ReviewBiochemical Society transactions2020

RNA matchmaking in chromatin regulation.

Stephen K Wu, Justin T Roberts, Maggie M Balas, Aaron M Johnson

Abstract readReview
In one paragraph

Review in Biochemical Society transactions, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Research Progress on Non-coding RNAs in Cholesteatoma of the Middle Ear.Clinical and experimental otorhinolaryngology · 2023
    Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephen K Wu *Molecular Biology Program, University of Colorado, Denver Anschutz Medical Campus 12801 East 17th Ave., Aurora, CO, U.S.A.
Justin T Roberts *Molecular Biology Program, University of Colorado, Denver Anschutz Medical Campus 12801 East 17th Ave., Aurora, CO, U.S.A.
Maggie M Balas *Molecular Biology Program, University of Colorado, Denver Anschutz Medical Campus 12801 East 17th Ave., Aurora, CO, U.S.A.
Aaron M JohnsonMolecular Biology Program, University of Colorado, Denver Anschutz Medical Campus 12801 East 17th Ave., Aurora, CO, U.S.A.

Funding

Predoctoral Training Program in Molecular BiologyT32GM008730 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI PREKERIS, RYTIS, SCLAFANI, ROBERT A · 1999 to 2019
$3.3M
Mechanisms of heterochromatin targeting and epigenetic genome regulationR35GM119575 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI JOHNSON, AARON M. · 2016 to 2020
$1.9M
Role of hypoxia in altering hnRNP A2B1-mediated interaction with m6A to promote breast cancer progressionF31CA247343 · NCI · UNIVERSITY OF COLORADO DENVER · PI ROBERTS, JUSTIN T · 2020 to 2021
$61k
NCI NIH HHS F31 CA247343NIGMS NIH HHS R35 GM119575NIGMS NIH HHS T32 GM008730
6 · The paper itself

Abstract

Beyond being the product of gene expression, RNA can also influence the regulation of chromatin. The majority of the human genome has the capacity to be transcribed and the majority of the non-protein-coding transcripts made by RNA Polymerase II are enriched in the nucleus. Many chromatin regulators can bind to these ncRNAs in the nucleus; in some cases, there are clear examples of direct RNA-mediated chromatin regulation mechanisms stemming from these interactions, while others have yet to be determined. Recent studies have highlighted examples of chromatin regulation via RNA matchmaking, a term we use broadly here to describe intermolecular base-pairing interactions between one RNA molecule and an RNA or DNA match. This review provides examples of RNA matchmaking that regulates chromatin processes and summarizes the technical approaches used to capture these events.

Indexed as

Gene Expression RegulationAnimalsArabidopsisCell NucleusChromatinDNAEpigenesis, GeneticGene Expression ProfilingGene SilencingGenome, FungalGenome, HumanHistonesHumansMiceNucleic Acid ConformationRNAChromatinDNAHistonesRNARNA, Long NoncodingRNA, Small InterferingRNA, UntranslatedchromatinlncRNApiRNARNA matchmaking

Identifiers

PMID33245317
PMCPMC7888525

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.