Evidence map›Paper›PMID 33245194›Full record

ArticleChemMedChem2021

Sascha Häseli, Marion Holy, Markus Joksch, Carina Bergner, Andreas Wree, Jens Kurth, Aylin Cankaya, Markus Piel, Bernd J Krause, Harald H Sitte and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Tropanes in natural products, syntheses, and drugs: some insights from the new millennium.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. ChemMedChem · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Sascha HäseliInstitute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
Marion HolyInstitute of Pharmacology (Center for Physiology and Pharmacology), Medical University of Vienna, Währinger Straße 13a, 1090, Wien, Austria.
Markus JokschDepartment of Nuclear Medicine, Rostock University Medical Center, Gertrudenplatz 1, 18057, Rostock, Germany.
Carina BergnerDepartment of Nuclear Medicine, Rostock University Medical Center, Gertrudenplatz 1, 18057, Rostock, Germany.
Andreas WreeInstitute of Anatomy, Rostock University Medical Center, Gertrudenstraße 9, 18057, Rostock, Germany.
Jens KurthDepartment of Nuclear Medicine, Rostock University Medical Center, Gertrudenplatz 1, 18057, Rostock, Germany.
Aylin CankayaInstitute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
Markus PielInstitute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
Bernd J KrauseDepartment of Nuclear Medicine, Rostock University Medical Center, Gertrudenplatz 1, 18057, Rostock, Germany.
Harald H SitteInstitute of Pharmacology (Center for Physiology and Pharmacology), Medical University of Vienna, Währinger Straße 13a, 1090, Wien, Austria.
Frank RöschInstitute of Nuclear Chemistry, Johannes Gutenberg-University Mainz, Fritz-Strassmann-Weg 2, 55128, Mainz, Germany.
University of Rostock · DEJohannes Gutenberg University Mainz · DEMedical University of Vienna · AT

Funding

Viennese Fund for Science and Technology CS15-033
6 · The paper itself

Abstract

The development of radiometal-labelled pharmaceuticals for neuroimaging could offer great potential due to easier handling during labelling and availability through radionuclide generator systems. Nonetheless, to date, no such tracers are available for positron emission tomography, primarily owing to the challenge of crossing the blood-brain barrier (BBB) and loss of affinity through chelator attachment. We have prepared a variety of

Indexed as

AnimalsBlood-Brain BarrierDopamine Plasma Membrane Transport ProteinsDose-Response Relationship, DrugGallium RadioisotopesMaleMolecular StructurePositron-Emission TomographyRadiopharmaceuticalsRatsRats, WistarStructure-Activity RelationshipTropanesDopamine Plasma Membrane Transport ProteinsGallium RadioisotopesRadiopharmaceuticalsTropanesdopamine transportersgallium-68imaging agentslipophilicityradiopharmaceuticalstropane

Identifiers

PMID33245194
PMCPMC7984292
OpenAlexW3107413837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.