ArticleVeterinary dermatology2021
Clinical efficacy of spray-based heat-treated lactobacilli in canine atopic dermatitis: a preliminary, open-label, uncontrolled study.
Article in Veterinary dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Probiotics as an adjunct in the treatment of canine atopic dermatitis: a systematic review and meta-analysis of in vivo studies in dogs.The Journal of veterinary medical science · 2025Pooled it
- Clinical Efficacy of Probiotic-Based Ear Drops Containing Lactobacilli in Canine Erythroceruminous Otitis Externa: An Open Label, Multicentre Study.Veterinary dermatology · 2026Article
- Some of the Newest Therapeutic Methods in Canine Atopic Dermatitis.Veterinary sciences · 2026Review
- Postbiotics and Parabiotics in Veterinary Medicine: A Market Overview.Probiotics and antimicrobial proteins · 2026Review
- Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo.Veterinary dermatology · 2026Article
- Efficacy of Lacticaseibacillus rhamnosus GG in the treatment of canine atopic dermatitis: A randomized controlled study.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- A refined comparative mouse model of acute and chronic atopic dermatitis.Journal of animal science and technology · 2025Article
- A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs.Animals : an open access journal from MDPI · 2024Article
- The role of the microbiome in allergic dermatitis-related otitis externa: a multi-species comparative review.Frontiers in veterinary science · 2024Review
- Primary Prevention of Canine Atopic Dermatitis: Breaking the Cycle-A Narrative Review.Veterinary sciences · 2023Review
- Detecting common allergens in dogs with atopic dermatitis in South Korean Provinces using a serological immunoglobulin E-specific allergen test.Veterinary world · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCanine atopic dermatitis (cAD) is a common inflammatory and pruritic skin disease, with various treatment options. The use of topical products containing natural ingredients has proven increasingly popular.
objectiveTo evaluate the effects of a spray solution containing heat-killed Lactobacillus rhamnosus and L. reuteri, on the clinical signs and cutaneous microbiota of atopic dogs. ANIMALS: Ten privately owned, mildly affected, nonseasonally atopic dogs. METHODS AND MATERIALS: The spray was applied to the ventrum every 24 h for 28 days. Clinical scores, skin barrier function and owner assessment were evaluated on day (D)0, D14, D28 and D42. The cutaneous microbiota was analysed on D0 and D28.
resultsA reduction in the total clinical score was seen at each time point (D14, P = 0.03; D28, P = 0.04; D42, P = 0.001). A reduction in the regional clinical scores was seen after D28 (P = 0.01) and D42 (P = 0.003). A significant reduction in the pruritus score was seen on D42 (P = 0.01). A lower hydration value was seen on D28 (P = 0.02) and D42 (P = 0.02) on the pinnae. A good-to-excellent response and an easy-to-use administration was reported by owners. There were no significant changes in the cutaneous microbiota after 28 days. CONCLUSIONS AND CLINICAL IMPORTANCE: There was a significant and rapid decrease in the clinical signs associated with cAD after use of the spray. Future larger, randomized, controlled studies are needed to confirm these results and to assess the effects on the cutaneous immunity and microflora of atopic dogs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.