Evidence map›Paper›PMID 33245130›Full record

Trial reportThe Journal of nutrition2021

Weight Loss, but Not Dairy Composition of Diet, Moderately Affects Satiety and Postprandial Gut Hormone Patterns in Adults.

Sridevi Krishnan, Sean H Adams, Megan G Witbracht, Leslie R Woodhouse, Brian D Piccolo, Anthony P Thomas, Elaine C Souza, William F Horn, Erik R Gertz, Marta D Van Loan and 1 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00858312 (Role of Dairy Foods to Enhance Central Fat and Weight Loss With Moderate Energy Restriction in Overweight and Obesity Individuals), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00858312 nacompletednot on this map

Role of Dairy Foods to Enhance Central Fat and Weight Loss With Moderate Energy Restriction in Overweight and Obesity Individuals

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2006 to 2009Enrolled78ConditionsOverweight and ObesityArmshigh dairy diet, Low Dairy
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sridevi KrishnanDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Sean H AdamsDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Megan G WitbrachtDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Leslie R WoodhouseWestern Human Nutrition Research Center, USDA Agricultural Research Service, Davis, CA, USA.
Brian D PiccoloDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Anthony P ThomasDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Elaine C SouzaWestern Human Nutrition Research Center, USDA Agricultural Research Service, Davis, CA, USA.
William F HornWestern Human Nutrition Research Center, USDA Agricultural Research Service, Davis, CA, USA.
Erik R GertzWestern Human Nutrition Research Center, USDA Agricultural Research Service, Davis, CA, USA.
Marta D Van LoanDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
Nancy L KeimDepartment of Nutrition, University of California, Davis, Davis, CA, USA.
University of California, Davis · USWestern Human Nutrition Research Center · USAgricultural Research Service · US

Funding

UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
NCRR NIH HHS UL1 RR024146
6 · The paper itself

Abstract

backgroundInclusion of dairy in diet patterns has been shown to have mixed effects on weight loss. A prevailing hypothesis is that dairy improves weight loss by influencing endocrine systems associated with satiety and food intake regulation.

objectivesThe objective of the current study was to evaluate the effect of weight loss with or without adequate dietary dairy on subjective and objective appetitive measures.

methodsMen and women who were habitual low dairy consumers (n = 65, 20-50 y) participated in a 12-wk randomized controlled feeding weight loss trial. During the 12-wk intervention, a low-dairy (<1 serving dairy/d) was compared with an adequate-dairy (3-4 servings dairy/d) diet, both with a 500-kcal deficit/d. Test days, before and at the end of the intervention, began with 2 fasting blood draws and visual analog scale (VAS) measures, followed by a standard breakfast (25% of prescribed restricted calories), 5 postbreakfast blood draws and VASs, a standard lunch (40% of restricted energy amount), and 12 postlunch blood draws and VASs. Blood samples were used for satiety hormone measurements. On a separate day when matching standard meals were consumed, an ad libitum buffet meal was provided as dinner, at a self-selected time. Meal duration and intermeal interval were recorded.

resultsWeight loss (-6.1 kg), irrespective of dairy, resulted in reduced fasting insulin (-20%) and leptin (-25%), and increased fasting acylated ghrelin (+25%) and VAS desire to eat (+18%) (P < 0.05). There were no effects of dairy on objective or subjective satiety measures. Weight loss marginally reduced the intermeal interval (289 min compared with 276 min, P = 0.059) between lunch and the ad libitum buffet.

conclusionsThese results do not support the hypothesis that inclusion of dairy in long-term dietary patterns influences appetite during weight loss. Weight loss per se has a modest impact on select systems that regulate hunger and satiety.This trial was registered at clinicaltrials.gov as NCT00858312.

Indexed as

Dairy ProductsDietPostprandial PeriodSatiety ResponseWeight LossAdultFemaleGastrointestinal TractGhrelinHumansInsulinLeptinMaleMiddle AgedYoung AdultGhrelinInsulinLeptinad libitum buffetappetitedairydesire to eatghrelinleptinsatietyweight loss

Identifiers

PMID33245130
PMCPMC8096231
OpenAlexW3107683344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.