ArticleSocial cognitive and affective neuroscience2020
Childhood trauma, brain structure and emotion recognition in patients with schizophrenia and healthy participants.
Article in Social cognitive and affective neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- A Systematic Review and Meta-Analysis of Social Cognition Among People Living with HIV: Implications for Non-Social Cognition and Social Everyday Functioning.Neuropsychology review · 2025Pooled it
- Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis.Psychological medicine · 2023Pooled it
- Role of childhood trauma in interoception and alexithymia in schizophrenia.Journal of psychiatric research · 2026Article
- The mediating effect of alexithymia between childhood trauma and negative symptoms in chronic schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Neural effect of childhood maltreatment on neurovascular coupling in adolescent depression.European child & adolescent psychiatry · 2025Article
- The role of metacognition and social cognition in childhood trauma effecting on prognosis: 1-year follow-up study in patients with first-episode schizophrenia.BMC psychiatry · 2025Article
- Depressive and Negative Symptoms in the Early and Established Stages of Schizophrenia: Integrating Structural Brain Alterations, Cognitive Performance, and Plasma Interleukin 6 Levels.Biological psychiatry global open science · 2025Article
- Independent effects of early life adversity on social cognitive function in patients with schizophrenia.Frontiers in psychiatry · 2024Article
- The effect of childhood trauma on moral cognition in patients with schizophrenia.Frontiers in psychiatry · 2024Article
- Sexual abuse and psychotic phenomena: a directed acyclic graph analysis of affective symptoms using English national psychiatric survey data.Psychological medicine · 2023Article
- The impact of early adversity and education on genetic and brain morphological predictors of cognitive ability.Genes, brain, and behavior · 2023Article
- Early life stress, low-grade systemic inflammation and weaker suppression of the default mode network (DMN) during face processing in Schizophrenia.Translational psychiatry · 2023Article
- Structural brain correlates of childhood trauma with replication across two large, independent community-based samples.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Adverse childhood experiences in patients with schizophrenia: related factors and clinical implications.Frontiers in psychiatry · 2023Article
- Developmental Manipulation-Induced Changes in Cognitive Functioning.Current topics in behavioral neurosciences · 2023Article
- Bridging the Gap Between Environmental Adversity and Neuropsychiatric Disorders: The Role of Transposable Elements.Frontiers in genetics · 2022Review
- Microglial-expressed genetic risk variants, cognitive function and brain volume in patients with schizophrenia and healthy controls.Translational psychiatry · 2021Article
- Effect of child abuse and neglect on schizophrenia and other psychotic disorders.Pharmacology, biochemistry, and behavior · 2021Review
- Childhood maltreatment and social functioning in psychotic disorders: a systematic review protocol.European journal of psychotraumatology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood trauma, and in particular physical neglect, has been repeatedly associated with lower performance on measures of social cognition (e.g. emotion recognition tasks) in both psychiatric and non-clinical populations. The neural mechanisms underpinning this association have remained unclear. Here, we investigated whether volumetric changes in three stress-sensitive regions-the amygdala, hippocampus and anterior cingulate cortex (ACC)-mediate the association between childhood trauma and emotion recognition in a healthy participant sample (N = 112) and a clinical sample of patients with schizophrenia (N = 46). Direct effects of childhood trauma, specifically physical neglect, on Emotion Recognition Task were observed in the whole sample. In healthy participants, reduced total and left ACC volumes were observed to fully mediate the association between both physical neglect and total childhood trauma score, and emotion recognition. No mediating effects of the hippocampus and amygdala volumes were observed for either group. These results suggest that reduced ACC volume may represent part of the mechanism by which early life adversity results in poorer social cognitive function. Confirmation of the causal basis of this association would highlight the importance of resilience-building interventions to mitigate the detrimental effects of childhood trauma on brain structure and function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.