Evidence map›Paper›PMID 33245046›Full record

ArticleeLife2020

Increasing heart vascularisation after myocardial infarction using brain natriuretic peptide stimulation of endothelial and WT1

Na Li, Stephanie Rignault-Clerc, Christelle Bielmann, Anne-Charlotte Bon-Mathier, Tamara Déglise, Alexia Carboni, Mégane Ducrest, Nathalie Rosenblatt-Velin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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  7. Drug design, development and therapy · 2024
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  13. Longitudinal peripheral tissue RNA-Seq transcriptomic profiling, hyperalgesia, and wound healing in the rat plantar surgical incision model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Na LiDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Stephanie Rignault-ClercDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Christelle BielmannDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Anne-Charlotte Bon-MathierDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Tamara DégliseDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Alexia CarboniDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Mégane DucrestDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Nathalie Rosenblatt-VelinDivision of Angiology, Heart and Vessel Department, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2011-2862
Kobe Pharmaceutical University · JPUniversity Hospital of Lausanne · CH

Funding

Emma Muschamp Foundation F34567Novartis Stiftung für Medizinisch-Biologische Forschung 17B079Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung PMPDB310030_162985
6 · The paper itself

Abstract

Brain natriuretic peptide (BNP) treatment increases heart function and decreases heart dilation after myocardial infarction (MI). Here, we investigated whether part of the cardioprotective effect of BNP in infarcted hearts related to improved neovascularisation. Infarcted mice were treated with saline or BNP for 10 days. BNP treatment increased vascularisation and the number of endothelial cells in all areas of infarcted hearts. Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. BNP also stimulated the proliferation of WT1

Indexed as

AnimalsAnimals, NewbornAtrial Natriuretic Factor Receptor BCells, CulturedEndothelial CellsGene Expression RegulationMaleMiceMice, KnockoutNatriuretic Peptide, BrainPericardiumReceptors, Atrial Natriuretic FactorWT1 Proteinsatrial natriuretic factor receptor AAtrial Natriuretic Factor Receptor BNatriuretic Peptide, BrainReceptors, Atrial Natriuretic FactorWT1 protein, mouseWT1 Proteinsangiogenesisbrain natriuretic peptidecell biologyendothelial cellsheartmouseprecursorsregenerative medicinestem cells

Identifiers

PMID33245046
PMCPMC7695454
OpenAlexW3108202447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.