ArticleeLife2020
Precisely timed dopamine signals establish distinct kinematic representations of skilled movements.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 66 citations in OpenAlex.
- Disruption of dopamine D2/D3 system function impairs the human ability to understand the mental states of other people.PLoS biology · 2024Trial
- Dopamine modulation of motor and implicit learning contributions to auditory temporal attention.iScience · 2026Article
- Distinct forms of dopamine transmission control locomotion and learning.bioRxiv : the preprint server for biology · 2026Article
- Striatal Dopamine at Learned Sequence Boundaries Sustains Birdsong.bioRxiv : the preprint server for biology · 2026Article
- The role of dopamine-sensitive motor cortical circuits in the development and execution of skilled forelimb movements.iScience · 2026Article
- Subsecond dopamine fluctuations do not specify the vigor of ongoing actions.Nature neuroscience · 2025Article
- Dopamine dynamics underlying maternal motivation and reward.Neuroscience research · 2025Review
- Neurobiology of Dystonia: Review of Genetics, Animal Models, and Neuroimaging.Brain sciences · 2025Review
- Striatal Dopamine Actions and Movement: Inferences from Parkinson Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- VTA projections to M1 are essential for reorganization of layer 2-3 network dynamics underlying motor learning.Nature communications · 2025Article
- Article
- Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.International journal of molecular sciences · 2024Review
- Nanoplasmonic aptasensor for sensitive, selective, and real-time detection of dopamine from unprocessed whole blood.Science advances · 2024Article
- Explaining dopamine through prediction errors and beyond.Nature neuroscience · 2024Review
- Striatal Dopamine Contributions to Skilled Motor Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Use of Compounds Derived fromInternational journal of molecular sciences · 2024Review
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Open-Source Platform for Kinematic Analysis of Mouse Forelimb Movement.bioRxiv : the preprint server for biology · 2024Article
- Dopamine receptors of the rodent fastigial nucleus support skilled reaching for goal-directed action.Brain structure & function · 2024Article
- Striatal dopamine contributions to skilled motor learning.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Brain dopamine is critical for normal motor control, as evidenced by its importance in Parkinson Disease and related disorders. Current hypotheses are that dopamine influences motor control by 'invigorating' movements and regulating motor learning. Most evidence for these aspects of dopamine function comes from simple tasks (e.g. lever pressing). Therefore, the influence of dopamine on motor skills requiring multi-joint coordination is unknown. To determine the effects of precisely timed dopamine manipulations on the performance of a complex, finely coordinated dexterous skill, we optogenetically stimulated or inhibited midbrain dopamine neurons as rats performed a skilled reaching task. We found that reach kinematics and coordination between gross and fine movements progressively changed with repeated manipulations. However, once established, rats transitioned abruptly between aberrant and baseline reach kinematics in a dopamine-dependent manner. These results suggest that precisely timed dopamine signals have immediate and long-term influences on motor skill performance, distinct from simply 'invigorating' movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.