ArticleeLife2020
Frontal eye field and caudate neurons make different contributions to reward-biased perceptual decisions.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.eLife · 2026Article
- The neurocognitive aspects of empathy and theory of mind in pragmatic language processing.Cognitive, affective & behavioral neuroscience · 2026Article
- Distinct involvements of the subthalamic nucleus subpopulations in reward-biased decision-making in monkeys.bioRxiv : the preprint server for biology · 2025Article
- A population representation of the confidence in a decision in the parietal cortex.Cell reports · 2025Article
- Article
- The neural activity of auditory conscious perception.NeuroImage · 2025Article
- A Population Representation of the Confidence in a Decision in the Parietal Cortex.bioRxiv : the preprint server for biology · 2025Article
- Article
- Neural Representations of Post-Decision Accuracy and Reward Expectation in the Caudate Nucleus and Frontal Eye Field.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Contributions of the Basal Ganglia to Visual Perceptual Decisions.Annual review of vision science · 2023Review
- Neurons in human pre-supplementary motor area encode key computations for value-based choice.Nature human behaviour · 2023Article
- Neural Mechanisms That Make Perceptual Decisions Flexible.Annual review of physiology · 2023Review
- Reinforcement-learning in fronto-striatal circuits.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Long term study of motivational and cognitive effects of low-intensity focused ultrasound neuromodulation in the dorsal striatum of nonhuman primates.Brain stimulationArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Many decisions require trade-offs between sensory evidence and internal preferences. Potential neural substrates include the frontal eye field (FEF) and caudate nucleus, but their distinct roles are not understood. Previously we showed that monkeys' decisions on a direction-discrimination task with asymmetric rewards reflected a biased accumulate-to-bound decision process (Fan et al., 2018) that was affected by caudate microstimulation (Doi et al., 2020). Here we compared single-neuron activity in FEF and caudate to each other and to accumulate-to-bound model predictions derived from behavior. Task-dependent neural modulations were similar in both regions. However, choice-selective neurons in FEF, but not caudate, encoded behaviorally derived biases in the accumulation process. Baseline activity in both regions was sensitive to reward context, but this sensitivity was not reliably associated with behavioral biases. These results imply distinct contributions of FEF and caudate neurons to reward-biased decision-making and put experimental constraints on the neural implementation of accumulation-to-bound-like computations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.