Evidence map›Paper›PMID 33244876›Full record

ArticleThe clinical respiratory journal2021

Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers.

Xiaoyu Liu, Anthony P Reeves, Katherine Antoniak, Raúl San José Estépar, John T Doucette, Yunho Jeon, Jonathan Weber, Dongming Xu, Juan C Celedón, Rafael E de la Hoz

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in The clinical respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03295279 (Pulmonary Diseases in WTC Workers), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03295279 enrolling by invitationnot on this map

Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT Correlates

TypeobservationalSponsorIcahn School of Medicine at Mount SinaiRan2012 to 2027Enrolled2,122ConditionsChronic Airway Disease, Interstitial Lung Disease, Lung Cancer
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Xiaoyu LiuDepartments of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-6528-0213
Anthony P ReevesSchool of Electrical and Computer Engineering, Cornell University, Ithaca, NY, USA.ORCID https://orcid.org/0000-0002-1451-3080
Katherine AntoniakDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-0997-4261
Raúl San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, USA.ORCID https://orcid.org/0000-0002-3677-1996
John T DoucetteDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0001-8985-0367
Yunho JeonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-2923-3284
Jonathan WeberDepartment of Research and Education, Saint Francis Hospital, Roslyn, NY, USA.ORCID https://orcid.org/0000-0002-6847-8057
Dongming XuDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-1299-9435
Juan C CeledónDivision of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-6139-5320
Rafael E de la HozDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID https://orcid.org/0000-0002-8949-9279
Icahn School of Medicine at Mount Sinai · USBrigham and Women's Hospital · USCornell University · USSaint Francis University · USUniversity of Pittsburgh · US

Funding

Pulmonary Diseases in WTC Workers: Symptoms, Function, and Chest CT CorrelatesU01OH010401 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DE LA HOZ, RAFAEL E. · 2012 to 2025
$7.3M
International Exchange Program for Minority StudentsT37MD001452 · NIMHD · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CLAUDIO, LUZ · 2005 to 2023
$4.9M
Airway Inspector: a chest imaging biomarker software platform for COPDR01HL116931 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SAN JOSE ESTEPAR, RAUL · 2013 to 2017
$2.2M
Short-term Research Training Program for Minority StudentsR25HL108857 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Luz Claudio · 2011 to 2026
$1.9M
Chronic Obstructive Pulmonary Disease in WTC Workers - Diagnoses and TransitionsU01OH011697 · OH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DE LA HOZ, RAFAEL E. · 2018 to 2025
$1.9M
American Thoracic SocietyCDC HHS 2019CDC HHS NCT03295279CLC NIH HHSNHLBI NIH HHS R01 HL116931NHLBI NIH HHS R25 HL108857NIMHD NIH HHS T37 MD001452NIOSH CDC HHS 200-2017-93325NIOSH CDC HHS U01 OH010401NIOSH CDC HHS U01 OH011697School of MedicineUniversity of Pennsylvania
6 · The paper itself

Abstract

backgroundOccupational exposures at the WTC site after 11 September 2001 have been associated with presumably inflammatory chronic lower airway diseases.

aimsIn this study, we describe the trajectories of expiratory air flow decline, identify subgroups with adverse progression, and investigate the association of those trajectories with quantitative computed tomography (QCT) imaging measurement of increased and decreased lung density.

methodsWe examined the trajectories of expiratory air flow decline in a group of 1,321 former WTC workers and volunteers with at least three periodic spirometries, and using QCT-measured low (LAV%, -950 HU) and high (HAV%, from -600 to -250 HU) attenuation volume percent. We calculated the individual regression line slopes for first-second forced expiratory volume (FEV

resultsThe mean longitudinal FEV

conclusionsLongitudinal FEV

Indexed as

Lung DiseasesSeptember 11 Terrorist AttacksChildFemaleForced Expiratory VolumeHumansLungMaleOccupational ExposureTomography, X-Ray ComputedCT-lunghelical computed tomographyimaging of the chestinhalation injurylung function declinelung function trajectoriesmultivariate analysis of prognostic factorsoccupational respiratory diseasesWorld Trade Center-related lung disease

Identifiers

PMID33244876
PMCPMC8149480
OpenAlexW3107930795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.