Evidence map›Paper›PMID 33244524›Full record

ArticleCell reports. Physical science2020

Identifying Differing Intracellular Cargo Release Mechanisms by Monitoring

Panagiota Markopoulou, Nikolaos Panagiotou, Aurelia Li, Rocio Bueno-Perez, David Madden, Sarah Buchanan, David Fairen-Jimenez, Paul G Shiels, Ross S Forgan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Physical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Biomedical Applications of Metal-Organic Frameworks Revisited.Industrial & engineering chemistry research · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Panagiota MarkopoulouJoseph Black Building, College of Science and Engineering, School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Nikolaos PanagiotouJoseph Black Building, College of Science and Engineering, School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
Aurelia LiAdsorption & Advanced Materials Laboratory, Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK.
Rocio Bueno-PerezAdsorption & Advanced Materials Laboratory, Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK.
David MaddenAdsorption & Advanced Materials Laboratory, Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK.
Sarah BuchananWolfson Wohl Cancer Research Centre, College of Medical, Veterinary, & Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
David Fairen-JimenezAdsorption & Advanced Materials Laboratory, Department of Chemical Engineering & Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK.
Paul G ShielsWolfson Wohl Cancer Research Centre, College of Medical, Veterinary, & Life Sciences, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.
Ross S ForganJoseph Black Building, College of Science and Engineering, School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK.
University of Glasgow · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metal-organic frameworks (MOFs) have been proposed as biocompatible candidates for the targeted intracellular delivery of chemotherapeutic payloads, but the site of drug loading and subsequent effect on intracellular release is often overlooked. Here, we analyze doxorubicin delivery to cancer cells by MIL-101(Cr) and UiO-66 in real time. Having experimentally and computationally verified that doxorubicin is pore loaded in MIL-101(Cr) and surface loaded on UiO-66, different time-dependent cytotoxicity profiles are observed by real-time cell analysis and confocal microscopy. The attenuated release of aggregated doxorubicin from the surface of Dox@UiO-66 results in a 12 to 16 h induction of cytotoxicity, while rapid release of pore-dispersed doxorubicin from Dox@MIL-101(Cr) leads to significantly higher intranuclear localization and rapid cell death. In verifying real-time cell analysis as a versatile tool to assess biocompatibility and drug delivery, we show that the localization of drugs in (or on) MOF nanoparticles controls delivery profiles and is key to understanding

Indexed as

anticancerdoxorubicindrug deliveryin vitrometal-organic frameworksnanomedicinereal-time cell analysis

Identifiers

PMID33244524
PMCPMC7674849
OpenAlexW3106682573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.