ArticleFrontiers in genetics2020
Prognostic and Predictive Value of an Immunoscore Signature in Glioblastoma Multiform.
Article in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Immunologic specificity in glioblastoma: Antigen discovery and translational implications.Neuro-oncology advances · 2025Review
- Expression profile and prognostic values of Chromobox family members in human glioblastoma.Aging · 2022Article
- Friends with Benefits: Chemokines, Glioblastoma-Associated Microglia/Macrophages, and Tumor Microenvironment.International journal of molecular sciences · 2022Review
- Advances in CAR T cell immunotherapy for paediatric brain tumours.Frontiers in oncology · 2022Review
- A Fast and Efficient Approach to Obtaining High-Purity Glioma Stem Cell Culture.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough increasing evidence shows that immune infiltration plays an essential role in glioblastoma (GBM), current prognostic indicators do not accurately represent the risk of immune cells infiltration in patients. It is therefore critical to identify new prognostic markers for GBM. Here, we investigated the effectiveness of using immunoscore to improve risk stratification and prediction of prognosis in GBM patients receiving chemotherapy.
methodsUsing mRNA microarrays and CIBERSORT, we analyzed 22 types of immune cell fractions in 517 GBM samples and characterized an immunoscore using the least absolute shrinkage and selection operator (LASSO) Cox regression model based on the fraction of immune cell types and patients' overall survival. The prognostic and predictive accuracy of immunoscore was verified in the validation cohort and the entire cohort.
resultsUsing the LASSO model, an immunoscore was developed to classify patients into High and Low immunoscore groups in the training cohort (
conclusionImmunoscore, an immune-infiltration-based signature, is a reliable prognostic and predictive tool for GBM.
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Registered trials
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