Evidence map›Paper›PMID 33244234›Full record

ArticleInternational journal of nanomedicine2020

Effect of Starvation in Reversing Cancer Chemoresistance Based on Drug-Resistance Detection by Dextran Nanoparticles.

Chenglong Wang, Xuzhu Gao, Fanchen Wang, Wencai Guan, Hongjing Dou, Guoxiong Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chenglong WangResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, People's Republic of China.
Xuzhu GaoResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, People's Republic of China.
Fanchen WangResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, People's Republic of China.
Wencai GuanResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, People's Republic of China.
Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.
Guoxiong XuResearch Center for Clinical Medicine, Jinshan Hospital, Fudan University, Shanghai 201508, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChemoresistance leads to chemotherapy failure in patients with cancer. Multidrug resistance (MDR) in cancer is mainly caused by the high expression of P-glycoprotein encoded by the

methodsA starvation approach in reversing chemoresistance was applied, which was implemented through preparing fluorescent dextran-based nanoparticles to detect the proportion of chemoresistant cells in the chemoresistant/chemosensitive cell mixture after cells cultured in a low-glucose condition.

resultsChemoresistant cells had higher glucose consumption with higher ATPase expression and stronger glucose dependence compared to chemosensitive cells. Moreover, cancer cells cultured in a low-glucose condition reduced the proportion of chemoresistant cells.

conclusionStarvation therapy can be used as a new method to reverse drug resistance in cancer.

Indexed as

Drug Resistance, NeoplasmATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Cell Line, TumorDextransEscherichia coliFemaleFlow CytometryFluorescenceGene Expression Regulation, NeoplasticGlucoseHumansNanoparticlesNeoplasmsABCB1 protein, humanATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1DextransGlucosecancer drug-resistancenanoparticlesP-glycoproteinresistance reversalstarvation therapy

Identifiers

PMID33244234
PMCPMC7685360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.