Evidence map›Paper›PMID 33244118›Full record

ArticleScientific reports2020

Simultaneous evaluation of antioxidative serum profiles facilitates the diagnostic screening of autism spectrum disorder in under-6-year-old children.

Aki Hirayama, Keisuke Wakusawa, Toru Fujioka, Keiko Iwata, Noriyoshi Usui, Daisuke Kurita, Yosuke Kameno, Tomoyasu Wakuda, Shu Takagai, Takaharu Hirai and 7 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  8. Serum Free Radical Scavenging Capacity Profiles of Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 1 country.

Aki HirayamaCenter for Integrative Medicine, Tsukuba University of Technology, Tsukuba, Japan.
Keisuke WakusawaDepartment of Developmental Neuropsychiatry, Miyagi Children's Hospital, Sendai, Japan.
Toru FujiokaResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Keiko IwataResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Noriyoshi UsuiResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Daisuke KuritaDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Yosuke KamenoDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Tomoyasu WakudaDepartment of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Shu TakagaiUnited Graduate School of Child Development, Osaka University, Osaka, Japan.
Takaharu HiraiResearch Center for Child Mental Development, University of Fukui, Fukui, Japan.
Takahiro NaraDepartment of Developmental Neuropsychiatry, Miyagi Children's Hospital, Sendai, Japan.
Hiromu ItoGraduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Yumiko NaganoCenter for Integrative Medicine, Tsukuba University of Technology, Tsukuba, Japan.
Shigeru OowadaAsao Clinic, Kawasaki, Japan.
Masatsugu TsujiiSchool of Contemporary Sociology, Chukyo University, Toyota, Japan.
Kenji J TsuchiyaUnited Graduate School of Child Development, Osaka University, Osaka, Japan.
Hideo MatsuzakiResearch Center for Child Mental Development, University of Fukui, Fukui, Japan. matsuzah@u-fukui.ac.jp.
Hamamatsu University School of Medicine · JPUniversity of Fukui · JPMiyagi Children's Hospital · JPOsaka University · JPTsukuba University of Technology · JPChukyo University · JPKagoshima University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case-control study aimed to assess oxidative stress alterations in autism spectrum disorder (ASD). We used the MULTIS method, an electron spin resonance-based technique measuring multiple free radical scavenging activities simultaneously, in combination with conventional oxidative stress markers to investigate the ability of this MULTIS approach as a non-behavioural diagnostic tool for children with ASD. Serum samples of 39 children with ASD and 58 age-matched children with typical development were analysed. The ASD group showed decreased hydroxyl radical (

Indexed as

Oxidative StressAutism Spectrum DisorderBiomarkersCase-Control StudiesChildChild, PreschoolFemaleHumansMaleReactive Oxygen SpeciesUbiquinoneBiomarkerscoenzyme Q10Reactive Oxygen SpeciesUbiquinone

Identifiers

PMID33244118
PMCPMC7691362
OpenAlexW3109043982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.