ArticleScientific reports2020
Inter-fractional monitoring of [Formula: see text]C ions treatments: results from a clinical trial at the CNAO facility.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
- Out-of-beam artifact suppression in charged nuclear fragment based carbon-ion radiotherapy monitoring.Medical physics · 2026Article
- Detection of an internal density change in an anthropomorphic head phantom via tracking of charged nuclear fragments in carbon-ion radiotherapy.Medical physics · 2025Article
- Hybrid compton-PET imaging for ion-range verification: a preclinical study for proton, helium, and carbon therapy at HIT.European physical journal plus · 2025Article
- Feasibility study of 4D-online monitoring of density gradients induced by lung cancer treatment using carbon ions.Frontiers in oncology · 2025Article
- First experimental verification of prompt gamma imaging with carbon ion irradiation.Scientific reports · 2024Article
- Size-Sorted Superheated Nanodroplets for Dosimetry and Range Verification of Carbon-Ion Radiotherapy.Nanomaterials (Basel, Switzerland) · 2024Article
- An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors.Scientific reports · 2024Article
- Experience and new prospects of PET imaging for ion beam therapy monitoring.Zeitschrift fur medizinische Physik · 2023Review
- A simulation study of in-beam visualization system for proton therapy by monitoring scattered protons.Frontiers in medicine · 2023Article
- Ultrasound-assisted carbon ion dosimetry and range measurement using injectable polymer-shelled phase-change nanodroplets: in vitro study.Scientific reports · 2022Article
- Management of Motion and Anatomical Variations in Charged Particle Therapy: Past, Present, and Into the Future.Frontiers in oncology · 2022Review
- Monitoring Carbon Ion Beams Transverse Position Detecting Charged Secondary Fragments: Results From Patient Treatment Performed at CNAO.Frontiers in oncology · 2021Article
- Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking.Frontiers in oncology · 2021Article
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Authors and funding
41 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors in treatment planning, to prevent the tumor under-dosage related to the possible occurrence of inter-fractional morphological changes during a treatment. This limitation could be overcome by a range monitor, still missing in clinical routine, capable of providing on-line feedback. The Dose Profiler (DP) is a detector developed within the INnovative Solution for In-beam Dosimetry in hadronthErapy (INSIDE) collaboration for the monitoring of carbon ion treatments at the CNAO facility (Centro Nazionale di Adroterapia Oncologica) exploiting the detection of charged secondary fragments that escape from the patient. The DP capability to detect inter-fractional changes is demonstrated by comparing the obtained fragment emission maps in different fractions of the treatments enrolled in the first ever clinical trial of such a monitoring system, performed at CNAO. The case of a CNAO patient that underwent a significant morphological change is presented in detail, focusing on the implications that can be drawn for the achievable inter-fractional monitoring DP sensitivity in real clinical conditions. The results have been cross-checked against a simulation study.
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