ArticleScientific reports2020
Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Predictive nomogram for abdominal aortic calcification risk: a multi-algorithm approach integrating demographic and clinical variables.Journal of cardiothoracic surgery · 2026Article
- The long-term dialysis due to diabetic nephropathy may be associated with in-hospital death in patients with acute myocardial infarction.Heart and vessels · 2026Article
- Phosphate and Inflammation in Health and Kidney Disease.International journal of molecular sciences · 2025Review
- Low physical activity-related disease burden, 1990-2021: assessment of global trends and social determinants based on GBD 2021 data.Journal of global health · 2025Article
- Development and validation of a nomogram for predicting calcification of arteriovenous access in hemodialysis patients.Renal failure · 2025Article
- Patient characteristics modify the association between changes in mineral metabolism parameters and mortality in a nationwide hemodialysis cohort study.Scientific reports · 2025Article
- The Role of Mitochondrial Dysfunction in CKD-Related Vascular Calcification: From Mechanisms to Therapeutics.Kidney international reports · 2024Review
- AMPK-mediated autophagy is involved in the protective effect of canagliflozin in the vitamin D3 plus nicotine calcification model in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Cardiovascular calcification in hemodialysis patients: A Qatar-based prevalence and risk factors study.Qatar medical journal · 2024Article
- The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey.Frontiers in cardiovascular medicine · 2024Article
- Redox Metabolism and Vascular Calcification in Chronic Kidney Disease.Biomolecules · 2023Article
- Mitochondrial Dysfunction and Oxidative Stress in Hereditary Ectopic Calcification Diseases.International journal of molecular sciences · 2022Review
- Review
- Oxidative Stress in Calcific Aortic Valve Stenosis: Protective Role of Natural Antioxidants.Antioxidants (Basel, Switzerland) · 2022Review
- Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration.Materials today. Bio · 2022Article
- Bibliometric and Visual Analysis of Vascular Calcification Research.Frontiers in pharmacology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD). Particularly, CKD patients with diabetes mellitus (DM) develop severe VC. Specific mechanisms of VC remain unclear; this study aimed to investigate them in the context of coexisting CKD and DM, mainly regarding oxidative stress. Sprague Dawley rats were randomly divided into six groups as follows: control rats (Control), 5/6 nephrectomized rats (CKD), streptozotocin-injected rats (DM), 5/6 nephrectomized and streptozotocin-injected rats (CKD + DM), CKD + DM rats treated with insulin (CKD + DM + INS), and CKD + DM rats treated with antioxidant apocynin (CKD + DM + APO). At 18 weeks old, the rats were sacrificed for analysis. Compared to the control, DM and CKD groups, calcification of aortas significantly increased in the CKD + DM group. Oxidative stress and osteoblast differentiation-related markers considerably increased in the CKD + DM group compared with the other groups. Moreover, apocynin considerably reduced oxidative stress, osteoblast differentiation-related markers, and aortic calcification despite high blood glucose levels. Our data indicate that coexisting CKD and DM hasten VC primarily through an increase in oxidative stress; anti-oxidative therapy may prevent the VC progression.
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