Evidence map›Paper›PMID 33243931›Full record

ArticleOpen heart2020

Impact of timing of atrial fibrillation, CHA

Muzna Hussain, Rabel Misbah, Eoin Donnellan, Saqer Alkharabsheh, Yuan Hou, Feixiong Cheng, Michael Crookshanks, Chris J Watson, Andrew J Toth, Penny Houghtaling and 8 more

Open access · goldAbstract read
In one paragraph

Article in Open heart, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Muzna HussainDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID 0000-0003-1533-6634
Rabel MisbahDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Eoin DonnellanDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Saqer AlkharabshehDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Yuan HouDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Feixiong ChengDepartment of Genomic Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Michael CrookshanksDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Chris J WatsonCentre for Experimental Medicine, Queen's University Belfast, Belfast, County Antrim, UK.
Andrew J TothDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Penny HoughtalingDepartment of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, United States.
Rohit MoudgilDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
G Thomas BuddDepartment of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Deborah H KwonDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Wael JaberDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Brian GriffinDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Mohamad KanjDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Patrick CollierDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA colliep@ccf.org.
Cleveland Clinic · USCleveland Clinic Lerner College of Medicine · USQueen's University Belfast · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate timing and age distribution of atrial fibrillation (AF) in selected oncology patients, and the impact of AF timing, CHA

methodsThis is a retrospective cohort study of oncology patients referred to the cardio-oncology service from 2011 to 2018 for echocardiographic cardiosurveillance and/or pre-existing cardiovascular risk factor/disease management. Rates of first AF diagnosis was assessed using a parametric multiphase hazard model (predictive modelling) and non-parametrically by Kaplan-Meier with transformations tested using a bootstrap methodology.

resultsAmong 6754 patients identified, 174 patients had their first AF diagnosis

conclusionsThis study reports a nuanced/complex relationship between AF and cancer. First diagnosis of AF in patients with cancer was more common at/early after cancer diagnosis, especially in older patients and those exposed to cardiotoxic treatment. Pre-existing AF or a diagnosis of AF within 3 years after cancer diagnosis carried a negative prognosis. CHA

Indexed as

Propensity ScoreAgedAtrial FibrillationFollow-Up StudiesHumansMiddle AgedNeoplasmsPredictive Value of TestsPrognosisRetrospective StudiesRisk AssessmentRisk FactorsTime Factorsatrial fibrillationmalignancyrisk factors

Identifiers

PMID33243931
PMCPMC7692982
OpenAlexW3108486955

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.