ArticleAJNR. American journal of neuroradiology2021
Increased Perviousness on CT for Acute Ischemic Stroke is Associated with Fibrin/Platelet-Rich Clots.
Article in AJNR. American journal of neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07588061 (Comparative Effect of Maitland Mobilization Combined With Kendall Exercises on Pain and Postural Alignment in Adults With Upper Cross Syndrome), which is not on this map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effect of Maitland Mobilization Combined With Kendall Exercises on Pain and Postural Alignment in Adults With Upper Cross Syndrome
Who cites it
38 citing papers in PubMed, 63 citations in OpenAlex.
- Characterizing clot composition and stroke etiology through hounsfield units.Neuroradiology · 2026Article
- Clinical image analysis to build patient-specific models of acute ischemic stroke patients.Physical and engineering sciences in medicine · 2026Article
- CT-based intrathrombus and perithrombus radiomics for predicting complete recanalization after endovascular thrombectomy in acute ischemic stroke.Frontiers in neurology · 2026Article
- Thrombus Composition and the Evolving Role of Tenecteplase in Acute Ischemic Stroke.Journal of clinical medicine · 2025Article
- A Novel Nomogram for the Early Identification of Cardioembolic Stroke Using Clinical and Dual-Energy CT Features.Reviews in cardiovascular medicine · 2025Article
- Thrombus perviousness in acute ischemic stroke: a scoping review of methodology, predictive value, and future perspectives.Neuroradiology · 2025Article
- Can micro-guidewire advancement forces predict clot consistency and location to assist the first-line technique for mechanical thrombectomy?Journal of neurointerventional surgery · 2025Article
- Thrombus composition in ischaemic stroke: histological and radiological evaluation, and implications for acute clinical management.Journal of thrombosis and thrombolysis · 2025Review
- Vessel deviation during stent retrieval predicts successful recanalization in stent-based mechanical thrombectomy for M2 occlusion.Neuroradiology · 2025Article
- Histological analysis of thrombus composition in acute ischemic stroke with large vessel occlusion: impact of r-tPA treatment.Frontiers in neuroscience · 2025Article
- Contribution of Red Blood Cells and Platelets to Blood Clot Computed Tomography Imaging and Compressive Mechanical Characteristics.Annals of biomedical engineering · 2024Article
- Dynamic Perviousness Has Predictive Value for Clot Fibrin Content in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke : A Comparative Study of MT-Retrieved Clots and Clot Analogs.Clinical neuroradiology · 2024Article
- Impact of obesity-related indicators on first-pass effect in patients with ischemic stroke receiving mechanical thrombectomy.Neuroradiology · 2024Article
- Clot-based time attenuation curve as a novel imaging predictor of mechanical thrombectomy functional outcome in acute ischemia stroke.European radiology · 2024Article
- Dynamic Perviousness Predicts Revascularization Success in Acute Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Electrical impedance measurements can identify red blood cell-rich content in acute ischemic stroke clotsResearch and practice in thrombosis and haemostasis · 2024Article
- Multimodal CT imaging of ischemic stroke thrombi identifies scale-invariant radiomic features that reflect clot biology.Journal of neurointerventional surgery · 2023Article
- Association of clot ultrastructure with clot perviousness in stroke patients.Scientific reports · 2023Article
- Gene expression profiles of ischemic stroke clots retrieved by mechanical thrombectomy are associated with disease etiology.Journal of neurointerventional surgery · 2023Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 5 countries.
Funding
Abstract
background and purposeClot perviousness in acute ischemic stroke is a potential CT imaging biomarker for mechanical thrombectomy efficacy. We investigated the association among perviousness, clot cellular composition, and first-pass effect. MATERIALS AND
methodsIn 40 mechanical thrombectomy-treated cases of acute ischemic stroke, we calculated perviousness as the difference in clot density on CT angiography and noncontrast CT. We assessed the proportion of fibrin/platelet aggregates, red blood cells, and white blood cells on clot histopathology. We tested for linear correlation between histologic components and perviousness, differences in components between "high" and "low" pervious clots defined by median perviousness, and differences in perviousness/composition between cases that did and did not achieve a first-pass effect.
resultsPerviousness significantly positively and negatively correlated with the percentage of fibrin/platelet aggregates (
conclusionsClot perviousness on CT is associated with a higher percentage of fibrin/platelet aggregate content. Histologic data and, to a lesser degree, perviousness may have value in predicting first-pass outcome. Imaging metrics that more strongly reflect clot biology than perviousness may be needed to predict a first-pass effect with high accuracy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.