Evidence map›Paper›PMID 33243844›Full record

ArticleThe European respiratory journal2021

EmPHasis-10 as a measure of health-related quality of life in pulmonary arterial hypertension: data from PHAR.

Marissa Borgese, David Badesch, Todd Bull, Murali Chakinala, Teresa DeMarco, Jeremy Feldman, H James Ford, Dan Grinnan, James R Klinger, Lena Bolivar and 10 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in The European respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
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  9. Clarification of author disclosures for fourThe European respiratory journal · 2025
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  14. Exploring the patient perspective in pulmonary hypertension.The European respiratory journal · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Marissa BorgeseDept of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7295-4143
David BadeschDivision of Pulmonary and Critical Care Medicine, University of Colorado, Denver, CO, USA.
Todd BullDivision of Pulmonary and Critical Care Medicine, University of Colorado, Denver, CO, USA.
Murali ChakinalaDivision of Pulmonary and Critical Care Medicine, Washington University at Barnes-Jewish, Saint Louis, MO, USA.
Teresa DeMarcoDivision of Cardiology, University of California San Francisco, San Francisco, CA, USA.
Jeremy FeldmanArizona Pulmonary Specialists, Phoenix, AZ, USA.
H James FordDivision of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dan GrinnanDivision of Pulmonary and Critical Care Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
James R KlingerDivision of Pulmonary and Critical Care Medicine, Brown University, Providence, RI, USA.
Lena BolivarPatient representative, USA.
Oksana A ShlobinInova Fairfax Hospital, Falls Church, VA, USA.
Robert P FrantzDivision of Cardiovascular Medicine, Mayo Clinic Rochester, Rochester, MN, USA.
Jeffery S SagerCottage Pulmonary Hypertension Center, Santa Barbara, CA, USA.
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, USA.
Steven KawutDivision of Pulmonary and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-7896-0608
Peter J LearyDivision of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
Michael P GrayPulmonary Hypertension Association, Silver Spring, MD, USA.ORCID 0000-0003-1154-3011
Rita A PopatDept of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA.
Roham T ZamanianDivision of Pulmonary and Critical Care Medicine, Stanford University School of Medicine, Stanford, CA, USA Zamanian@stanford.edu.
PHAR Study Group

Funding

Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
NHLBI NIH HHS K24 HL103844
6 · The paper itself

Abstract

introductionWhile the performance of the emPHasis-10 (e10) score has been evaluated against limited patient characteristics within the United Kingdom, there is an unmet need for exploring the performance of the e10 score among pulmonary arterial hypertension (PAH) patients in the United States.

methodsUsing the Pulmonary Hypertension Association Registry, we evaluated relationships between the e10 score and demographic, functional, haemodynamic and additional clinical characteristics at baseline and over time. Furthermore, we derived a minimally important difference (MID) estimate for the e10 score.

resultsWe analysed data from 565 PAH (75% female) adults aged mean±sd 55.6±16.0 years. At baseline, the e10 score had notable correlation with factors expected to impact quality of life in the general population, including age, education level, income, smoking status and body mass index. Clinically important parameters including 6-min walk distance and B-type natriuretic peptide (BNP)/N-terminal proBNP were also significantly associated with e10 score at baseline and over time. We generated a MID estimate for the e10 score of -6.0 points (range -5.0--7.6 points).

conclusionsThe e10 score was associated with demographic and clinical patient characteristics, suggesting that health-related quality of life in PAH is influenced by both social factors and indicators of disease severity. Future studies are needed to demonstrate the impact of the e10 score on clinical decision-making and its potential utility for assessing clinically important interventions.

Indexed as

Hypertension, PulmonaryPulmonary Arterial HypertensionAdultAgedFamilial Primary Pulmonary HypertensionFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsQuality of LifeUnited KingdomNatriuretic Peptide, BrainPeptide Fragments

Identifiers

PMID33243844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.