Evidence map›Paper›PMID 33243798›Full record

ArticleBMJ open2020

Associations between multimorbidity and glycaemia (HbA1c) in people with type 2 diabetes: cross-sectional study in Australian general practice.

Jason I Chiang, John Furler, Frances Mair, Bhautesh D Jani, Barbara I Nicholl, Sharmala Thuraisingam, Jo-Anne Manski-Nankervis

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jason I ChiangDepartment of General Practice and Primary Health Care, University of Melbourne, Melbourne, Victoria, Australia jason.chiang@unimelb.edu.au.ORCID 0000-0002-4370-8063
John FurlerDepartment of General Practice and Primary Health Care, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-0339-5848
Frances MairGeneral Practice and Primary Care, University of Glasgow, Glasgow, UK.
Bhautesh D JaniGeneral Practice and Primary Care, University of Glasgow, Glasgow, UK.
Barbara I NichollGeneral Practice and Primary Care, University of Glasgow, Glasgow, UK.
Sharmala ThuraisingamDepartment of General Practice and Primary Health Care, University of Melbourne, Melbourne, Victoria, Australia.
Jo-Anne Manski-NankervisDepartment of General Practice and Primary Health Care, University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-2153-3482
The University of Melbourne · AUUniversity of Glasgow · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the prevalence of multimorbidity as well as individual and combinations of long-term conditions (LTCs) in people with type 2 diabetes (T2D) attending Australian general practice, using electronic health record (EHR) data. We also examine the association between multimorbidity condition count (total/concordant(T2D related)/discordant(unrelated)) and glycaemia (glycated haemoglobin, HbA1c).

designCross-sectional study.

settingAustralian general practice.

participants69 718 people with T2D with a general practice encounter between 2013 and 2015 captured in the MedicineInsight database (EHR Data from 557 general practices and >3.8 million Australian patients). PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence of multimorbidity, individual and combinations of LTCs. Multivariable linear regression models used to examine associations between multimorbidity counts and HbA1c (%).

resultsMean (SD) age 66.42 (12.70) years, 46.1% female and mean (SD) HbA1c 7.1 (1.4)%. More than 90% of participants with T2D were living with multimorbidity. Discordant conditions were more prevalent (83.4%) than concordant conditions (69.9 %). The three most prevalent discordant conditions were: painful conditions (55.4%), dyspepsia (31.6%) and depression (22.8%). The three most prevalent concordant conditions were hypertension (61.4%), coronary heart disease (17.1%) and chronic kidney disease (8.5%). The three most common combinations of conditions were: painful conditions and hypertension (38.8%), painful conditions and dyspepsia (23.1%) and hypertension and dyspepsia (22.7%). We found no associations between any multimorbidity counts (total, concordant and discordant) or combinations and HbA1c.

conclusionsMultimorbidity was common in our cohort of people with T2D attending Australian general practice, but was not associated with glycaemia. Although we did not explore mortality in this study, our results suggest that the increased mortality in those with multimorbidity and T2D observed in other studies may not be linked to glycaemia. Interestingly, discordant conditions were more prevalent than concordant conditions with painful conditions being the second most common comorbidity. Better understanding of the implications of different patterns of multimorbidity in people with T2D will allow more effective tailored care.

Indexed as

Diabetes Mellitus, Type 2General PracticeAgedAustraliaChronic DiseaseComorbidityCross-Sectional StudiesFemaleGlycated HemoglobinHumansMaleMiddle AgedMultimorbidityPrevalenceGlycated Hemoglobindiabetes & endocrinologyepidemiologyprimary care

Identifiers

PMID33243798
PMCPMC7692835
OpenAlexW3109412194

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.