Evidence map›Paper›PMID 33243794›Full record

ArticleBMJ open2020

Pretreatment maternal lifestyle and outcomes of assisted reproduction: an Italian cohort study.

Elena Ricci, Stefania Noli, Stefania Ferrari, Irene La Vecchia, Valentina De Cosmi, Marta Castiglioni, Edgardo Somigliana, Carlo Agostoni, Sonia Cipriani, Paola Agnese Mauri and 1 more

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In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elena RicciDepartment of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy ed.ricci@libero.it.ORCID 0000-0001-5279-0444
Stefania NoliDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Stefania FerrariDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Irene La VecchiaDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Valentina De CosmiPediatric Intermediate Care Unit, Fondazione IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Marta CastiglioniDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Edgardo SomiglianaDepartment of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Carlo AgostoniDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.ORCID 0000-0002-5006-0832
Sonia CiprianiDepartment of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Paola Agnese MauriDepartment of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
Fabio ParazziniDepartment of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe investigated whether lifestyle affects assisted reproduction technology (ART) outcomes.

designCohort study.

settingItalian fertility unit.

participantsFrom September 2014 to December 2016, women from couples presenting for evaluation and eligible for ART were invited to participate. Information on alcohol intake, current smoking and leisure physical activity (PA) during the year before the interview was collected, using a structured questionnaire. We considered the ART outcomes of the cycle immediately following the interview. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was cumulative pregnancy rate per retrieval. Secondary measures were number of retrieved oocytes, embryo transfer and live birth.

resultsIn 492 women undergoing an ART cycle, 427 (86.8%) underwent embryo transfer, 157 (31.9%) had at least one clinical pregnancy and 121 (24.6%) had live birth. The cumulative pregnancy rate per retrieval was 33.3% (95% CI 28.5% to 38.7%). In women in the third tertile of alcohol intake, adjusted relative risk was 0.97 (95% CI 0.87 to 1.08), 0.90 (95% CI 0.62 to 1.30) and 0.89 (95% CI 0.57 to 1.37) for embryo transfer, clinical pregnancy and live birth, respectively. The corresponding figures in women currently smoking more than 5 cigarettes/day were 1.00 (95% CI 0.88 to 1.16), 0.94 (95% CI 0.60 to 1.48) and 1.14 (95% CI 0.68 to 1.90), and in women with PA ≥5 hours/week were 0.93 (95% CI 0.79 to 1.08), 0.44 (95% CI 0.22 to 0.90) and 0.48 (95% CI 0.22 to 1.05), respectively.

conclusionThere were no significant differences in in vitro fertilisation outcomes among women who used alcohol or tobacco in the year prior to treatment. Conservatively, all women should be advised to limit substance abuse. Moreover, our study suggested that maintaining a moderate, but not high, level of PA could be beneficial.

Indexed as

Embryo TransferLive BirthCohort StudiesFemaleFertilization in VitroHumansItalyLife StylePregnancyPregnancy RateReproductive Techniques, Assistedepidemiologyreproductive medicinesubfertility

Identifiers

PMID33243794
PMCPMC7692844

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.