Evidence map›Paper›PMID 33243793›Full record

ArticleBMJ open2020

Longitudinal cohort study of the impact of specialist cancer services for teenagers and young adults on quality of life: outcomes from the BRIGHTLIGHT study.

Rachel M Taylor, Lorna A Fern, Julie Barber, Javier Alvarez-Galvez, Richard Feltbower, Sarah Lea, Ana Martins, Stephen Morris, Louise Hooker, Faith Gibson and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
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  9. Treatment de-escalation for stage II seminoma.Nature reviews. Urology · 2023
    Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Reporting the whole story: Analysis of the 'out-of-scope' questions from the James Lind Alliance Teenage and Young Adult Cancer Priority Setting Partnership Survey.Health expectations : an international journal of public participation in health care and health policy · 2021
    Article
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Rachel M TaylorCentre for Nurse, Midwife and AHP Led Research (CNMAR), University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-0853-0925
Lorna A FernCancer Division, University College London Hospitals NHS Foundation Trust, London, UK lorna.fern@nhs.net.
Julie BarberDepartment of Statistical Science, University College, London, UK.
Javier Alvarez-GalvezDepartment of Biomedicine, Biotechnology and Public Health, University of Cadiz, Cadiz, Spain.ORCID 0000-0001-9512-7853
Richard FeltbowerSchool of Medicine, University of Leeds, Leeds, UK.
Sarah LeaCancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
Ana MartinsCancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
Stephen MorrisPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID 0000-0002-5828-3563
Louise HookerWessex Teenage and Young Adult Cancer Service, University Hospital Southampton, Southampton, UK.
Faith GibsonSchool of Health Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK.
Rosalind RaineDepartment of Applied Health Research, University College London, London, UK.
Dan P StarkLeeds Insitute of Molecular Medicine, University of Leeds, Leeds, UK.
Jeremy WhelanCancer Division, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0001-6793-5722
University College London Hospitals NHS Foundation Trust · GBUniversity College London · GBUniversity of Leeds · GBGreat Ormond Street Hospital for Children NHS Foundation Trust · GBUniversidad de Cádiz · ESUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

Department of Health RP-PG-1209-10013
6 · The paper itself

Abstract

objectivesIn England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children's cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTC

designLongitudinal cohort study.

settingHospitals delivering inpatient cancer care in England.

participants1114 young people aged 13 to 24 years newly diagnosed with cancer.

interventionExposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care. PRIMARY OUTCOME: Quality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis.

resultsGroup mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups.

conclusionsReceipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.

Indexed as

NeoplasmsQuality of LifeAdolescentAdultChildEnglandHumansLongitudinal StudiesProspective StudiesYoung Adultoncologyorganisation of health servicesquality in health care

Identifiers

PMID33243793
PMCPMC7692812
OpenAlexW3110585428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.