Evidence map›Paper›PMID 33243789›Full record

Observational studyBMJ open2020

Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study.

Katinka Nordheim Alme, Anne-Brita Knapskog, Halvor Næss, Mala Naik, Mona Beyer, Hanne Ellekjaer, Coralie English, Hege Ihle Hansen, Camilla Sollesnes Kummeneje, Ragnhild Munthe-Kaas and 5 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02650531 (Norwegian COgnitive Impairment After STroke), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02650531 completednot on this map

Norwegian COgnitive Impairment After STroke (NorCOAST) Study

TypeobservationalSponsorNorwegian University of Science and TechnologyRan2015 to 2018Enrolled816ConditionsDementia, Mild Cognitive Impairment, Stroke
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. A Home-Based Behaviour Change Intervention With Sedentary Behaviour and Physical Activity in People With Stroke and Diabetes-A Feasibility and Safety Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 2 countries.

Katinka Nordheim AlmeDepartment of Clinical Medicine (K1), University of Bergen, Bergen, Norway katinka.alme@gmail.com.ORCID 0000-0002-3925-4169
Anne-Brita KnapskogDepartment of Geriatric Medicine, Oslo University Hospital Ullevaal, Oslo, Norway.
Halvor NæssDepartment of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
Mala NaikDepartment of Internal Medicine, Haraldsplass Deaconess Hospital, Bergen, Norway.
Mona BeyerInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Hanne EllekjaerDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Coralie EnglishDivision of Health Sciences, International Centre for Allied health Evidence, University of South Australia Division of Health Sciences, Adelaide, South Australia, Australia.ORCID 0000-0001-5910-7927
Hege Ihle HansenInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Camilla Sollesnes KummenejeDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Ragnhild Munthe-KaasInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Yngve SeljesethDepartment of Internal Medicine, Aalesund Hospital, Alesund, Norway.
Xiangchung TanDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Pernille ThingstadDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Torunn AskimDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOOslo University Hospital · NOHaraldsplass Diakonale Sykehus · NOÅlesund Hospital · NOStavanger University Hospital · NOUniversity of Oslo · NOUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, and we have investigated the association between long-bout sedentary behaviour and long-term glucose levels in stroke survivors.

methodsThis study uses data from the Norwegian Cognitive Impairment After Stroke study, a multicentre cohort study. The patients were recruited at hospital admission for acute stroke, and the follow-up was done at the outpatient clinic. Sedentary behaviour-being in a sitting or reclining position-was registered 3 months after stroke using position transition data from the body-worn sensor activPAL attached to the unaffected thigh. A MATLAB script was developed to extract activity data from 08:00 to 10:00 for 4 days and to categorise the data into four bout-length categories. The primary outcome was glycated haemoglobin (HbA1c), analysed at 3 months. Regression models were used to analyse the association between HbA1c and sedentary behaviour in the whole population and stratified based on a diagnosis of diabetes mellitus (DM). Age, body mass index and the use of antidiabetic drugs were added as covariates into the models.

resultsFrom a total of 815 included patients, 379 patients fulfilled the inclusion criteria for this study. We found no association between time in sedentary behaviour and HbA1c in the whole stroke population. We found time in sedentary behaviour in bouts of ≥90 min to be associated with a higher HbA1c in patients with DM.

conclusionLong-bout sedentary time is associated with a higher HbA1c in patients with DM 3 months after ischaemic stroke. Future research should investigate the benefit of breaking up sedentary time as a secondary preventive measure. TRIAL REGISTRATION NUMBER: NCT02650531, https://clinicaltrials.gov/ct2/show/NCT02650531.

Indexed as

Brain IschemiaIschemic StrokeStrokeCohort StudiesGlucoseHumansProspective StudiesSedentary BehaviorGlucosediabetes and endocrinologysports medicinestroke medicinevascular medicine

Identifiers

PMID33243789
PMCPMC7692836
OpenAlexW3107150789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.