Evidence map›Paper›PMID 33243748›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2020

[IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy].

Lihua Wang, Xuan Zhang, Liangliang Wang, Beibei Wang, Jing Zhang, Yuzhi Li

Open access · greenAbstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lihua WangDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Xuan ZhangDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Liangliang WangDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Beibei WangDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Jing ZhangDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Yuzhi LiDepartment of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
Bengbu Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of interleukin-17A (IL-17A) on chemosensitivity of ovarian cancer cells to cisplatin (DDP) and explore the mechanism in light of autophagy regulation.

methodsOvarian cancer SKOV3 cells cultured

resultsDDP increased the expression of IL-17RA in ovarian cancer SKOV3 cells. Treatment with IL-17A significantly reduced the susceptibility of SKOV3 cells to cisplatin-induced apoptosis (

conclusionsIL-17A/IL-17RA can decrease chemosensitivity of SKOV3 cells to DDP by upregulating DDP-induced autophagy.

Indexed as

Ovarian NeoplasmsAntineoplastic AgentsApoptosisAutophagyCell Line, TumorCell ProliferationCisplatinDrug Resistance, NeoplasmFemaleHumansInterleukin-17Receptors, Interleukin-17Antineoplastic AgentsCisplatinIL17RA protein, humanInterleukin-17Receptors, Interleukin-17autophagycisplatindrug resistanceinterleukin-17Aovarian cancer

Identifiers

PMID33243748
PMCPMC7704378
OpenAlexW3107069645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.