Evidence map›Paper›PMID 33243665›Full record

ReviewMedical hypotheses2021

Same pollution sources for climate change might be hyperactivating the NLRP3 inflammasome and exacerbating neuroinflammation and SARS mortality.

David Macias-Verde, Pedro C Lara, Javier Burgos-Burgos

Open access · greenAbstract readReview
In one paragraph

Review in Medical hypotheses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Cumulative effects of air pollution and climate drivers on COVID-19 multiwaves in Bucharest, Romania.Process safety and environmental protection : transactions of the Institution of Chemical Engineers, Part B · 2022
    Article
  5. Observational
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David Macias-VerdeOncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain. Electronic address: david.macias@hospitalessanroque.com.
Pedro C LaraOncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain; Universidad Fernando Pessoa Canarias, Las Palmas, GC, Spain; Instituto Canario de Investigación del Cáncer, Tenerife, Spain.
Javier Burgos-BurgosOncology Department, Hospitales Universitarios San Roque, Las Palmas, GC, Spain.
Canary Institute of Cancer Research · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have reviewed a considerable amount of recent scientific papers relating inflammation caused by air pollution with chronic and severe medical conditions. Furthermore, there are evidences relating organ inflammation caused by not only outdoor long-term but also short-term inhaled radioisotopes contained in high polluted air or in household natural radioactive background aerosols, in addition to SARS-COV-2 attached to bioaerosols, which are related with a worst evolution of severe acute respiratory syndrome patients. Reactive oxygen species (ROS) production induced by the interaction with environmental ionizing radiation contained in pollution is pointed out as a critical mechanism that predispose mainly to elder population, but not excluding young subjects, presenting previous chronic conditions of lung inflammation or neuroinflammation, which can lead to the most serious consequences.

Indexed as

Climate ChangeAerosolsAir MicrobiologyAir Pollution, RadioactiveCausalityCOVID-19HumansInflammasomesInflammationModels, BiologicalNervous System DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinPandemicsParticle SizeParticulate MatterPneumoniaAerosolsInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanParticulate MatterAlzheimer’s diseaseARDSCOVID-19NLRP3 inflammasomePollutionRadioactivity

Identifiers

PMID33243665
PMCPMC7963803
OpenAlexW3100951018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.