Evidence map›Paper›PMID 33243071›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

Cerebral oxygen extraction fraction (OEF): Comparison of challenge-free gradient echo QSM+qBOLD (QQ) with

Junghun Cho, John Lee, Hongyu An, Manu S Goyal, Yi Su, Yi Wang

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 61 citations in OpenAlex.

  1. Imaging effective oxygen diffusivity in the human brain with multiparametric magnetic resonance imaging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  2. Brain oxygen extraction fraction mapping in patients with multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  3. Article
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  6. Article
  7. Article
  8. Article
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  11. Article
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  13. Article
  14. Sensitivity assessment of QSM+qBOLD (or QQ) in detecting elevated oxygen extraction fraction (OEF) in physiological change.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
    Article
  15. Review
  16. Spatial distribution of hyperpolarized [1-Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  17. Article
  18. Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  19. Validation of a new 3D quantitative BOLD based cerebral oxygen extraction mapping.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  20. Recent Advances in MR Imaging-based Quantification of Brain Oxygen Metabolism.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Junghun ChoDepartment of Radiology, Weill Cornell Medical College, New York, USA.ORCID 0000-0002-0826-5463
John LeeMallinkckrodt Institute of Radiology, Washington University School of Medicine, St Louis, USA.
Hongyu AnMallinkckrodt Institute of Radiology, Washington University School of Medicine, St Louis, USA.
Manu S GoyalMallinkckrodt Institute of Radiology, Washington University School of Medicine, St Louis, USA.ORCID 0000-0003-1970-4270
Yi SuComputational Image Analysis, Banner Alzheimer's Institute, Phoenix, USA.
Yi WangDepartment of Radiology, Weill Cornell Medical College, New York, USA.
Mallinckrodt (United States) · USCornell University · USAlzheimer's Association · US

Funding

Aerobic Glycolysis: A Marker of BrainResilience to Aging and Alzheimer's DiseaseR01AG057536 · NIA · WASHINGTON UNIVERSITY · PI GOYAL, MANU S, VLASSENKO, ANDREI G. · 2017 to 2021
$3.7M
Quantitative Mapping of Substantia Nigra Iron in Parkinson's DiseaseR01NS095562 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI SHTILBANS, ALEXANDER, WANG, YI · 2016 to 2022
$3.1M
Rapid, robust and non-invasive cerebral oxygenation measurements using MRIR01NS082561 · NINDS · WASHINGTON UNIVERSITY · PI AN, HONGYU · 2014 to 2018
$2.8M
No-Gd MRI for Monitoring Disease Status in Multiple SclerosisR01NS105144 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUTHIER, SUSAN A, GUPTA, AJAY · 2018 to 2022
$2.8M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4M
Multiple Sclerosis Lesion Magnetic Susceptibility ActivityR01NS090464 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2015 to 2020
$2.3M
3.0T Magnetic Resonance Imaging System for Preclinical, Translational and Clinical ResearchS10OD021782 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI WANG, YI · 2016 to 2016
$2.0M
Feasibility of challenge-free QSM based quantitative mapping of cerebral metabolic rate of oxygenR21EB024366 · NIBIB · WEILL MEDICAL COLL OF CORNELL UNIV · PI GOYAL, MANU S, SU, YI · 2017 to 2018
$474k
NIA NIH HHS R01 AG057536NIBIB NIH HHS R21 EB024366NIH HHS S10 OD021782NINDS NIH HHS P30 NS098577NINDS NIH HHS R01 NS082561NINDS NIH HHS R01 NS090464NINDS NIH HHS R01 NS095562NINDS NIH HHS R01 NS105144
6 · The paper itself

Abstract

We aimed to validate oxygen extraction fraction (OEF) estimations by quantitative susceptibility mapping plus quantitative blood oxygen-level dependence (QSM+qBOLD, or QQ) using

Indexed as

Cerebrovascular CirculationAdultBrainBrain MappingFemaleHealthy VolunteersHumansMaleOxygenOxygen ConsumptionOxygen RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsOxygenOxygen RadioisotopesRadiopharmaceuticalsOxygen extraction fractionpositron emission tomographyQSM+qBOLDquantitative blood oxygenation level-dependent imagingquantitative susceptibility mapping

Identifiers

PMID33243071
PMCPMC8221765
OpenAlexW3107579485

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.