Evidence map›Paper›PMID 33243051›Full record

ArticleInnate immunity2021

Endotoxemia is associated with an adverse metabolic profile.

Anne-Mari Määttä, Aino Salminen, Milla Pietiäinen, Jaakko Leskelä, Teemu Palviainen, Wolfgang Sattler, Juha Sinisalo, Veikko Salomaa, Jaakko Kaprio, Pirkko J Pussinen

Open access · goldAbstract readTwin Study
In one paragraph

Article in Innate immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Systemic Metabolic Signatures of Oral Diseases.Journal of dental research · 2024
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Chondroprotection of leptin deficiency demystified?Osteoarthritis and cartilage · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anne-Mari MäättäOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-5624-7729
Aino SalminenOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Milla PietiäinenOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jaakko LeskeläOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-9670-339X
Teemu PalviainenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Wolfgang SattlerDivision of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Juha SinisaloDepartment of Cardiology, Heart and Lung Center, Helsinki University Central Hospital, Helsinki, Finland.
Veikko SalomaaDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0001-7563-5324
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID 0000-0002-3716-2455
Pirkko J PussinenOral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-3563-1876
University of Helsinki · FIFinnish Institute for Health and Welfare · FIHelsinki University Hospital · FIMedical University of Graz · AT

Funding

ADOLESCENT ALCOHOL ABUSE: A TWIN-STUDY PERSPECTIVER37AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2000 to 2009
$2.9M
Adolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2M
USE &ABUSE OF ALCOHOL--A BEHAVIOR-GENETICS PERSPECTIVEK05AA000145 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1992 to 1996
–
BEHAVIORAL PRECURSORS OF ALCOHOLISM--TWIN FAMILY STUDIESR01AA009203 · NIAAA · INDIANA UNIVERSITY BLOOMINGTON · PI ROSE, RICHARD JOSEPH · 1994 to 1998
–
NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R37 AA012502
6 · The paper itself

Abstract

Our aim was to analyze whether endotoxemia, i.e. translocation of LPS to circulation, is reflected in the serum metabolic profile in a general population and in participants with cardiometabolic disorders. We investigated three Finnish cohorts separately and in a meta-analysis (

Indexed as

MetabolomeMetabolomicsAdolescentAdultAgedBody Mass IndexCohort StudiesCoronary DiseaseEndotoxemiaFemaleFinlandHeart DiseasesHumansLipid MetabolismLipidsLipopolysaccharidesLipidsLipopolysaccharidesEndotoxemiainfectioninflammationlipoproteinsmetabolic syndromemetabolomics

Identifiers

PMID33243051
PMCPMC7780360
OpenAlexW3093121067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.