Evidence map›Paper›PMID 33243025›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Analogues of 2'-hydroxychalcone with modified C4-substituents as the inhibitors against human acetylcholinesterase.

Sri Devi Sukumaran, Shah Bakhtiar Nasir, Jia Ti Tee, Michael J C Buckle, Rozana Othman, Noorsaadah Abd Rahman, Vannajan Sanghiran Lee, Syed Nasir Abbas Bukhari, Chin Fei Chee

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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sri Devi SukumaranFaculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Shah Bakhtiar NasirFaculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Jia Ti TeeFaculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Michael J C BuckleFaculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0003-2438-2376
Rozana OthmanFaculty of Medicine, Department of Pharmacy, University of Malaya, Kuala Lumpur, Malaysia.
Noorsaadah Abd RahmanFaculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0001-5847-8961
Vannajan Sanghiran LeeFaculty of Science, Department of Chemistry, University of Malaya, Kuala Lumpur, Malaysia.
Syed Nasir Abbas BukhariCollege of Pharmacy, Jouf University, Al-Jouf, Kingdom of Saudi Arabia.
Chin Fei CheeNanotechnology and Catalysis Research Centre, University of Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0002-5650-9119
University of Malaya · MYJouf University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of C4-substituted tertiary nitrogen-bearing 2'-hydroxychalcones were designed and synthesised based on a previous mixed type acetylcholinesterase inhibitor. Majority of the 2'-hydroxychalcone analogues displayed a better inhibition against acetylcholinesterase (AChE) than butyrylcholinesterase (BuChE). Among them, compound

Indexed as

AcetylcholinesteraseButyrylcholinesteraseChalconesCholinesterase InhibitorsDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity Relationship2'-hydroxychalconeAcetylcholinesteraseButyrylcholinesteraseChalconesCholinesterase InhibitorsacetylcholinesteraseAlzheimer’s diseasebutyrylcholinesterasechalconesmolecular modelling

Identifiers

PMID33243025
PMCPMC7822063
OpenAlexW3106873016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.