Evidence map›Paper›PMID 33242957›Full record

ArticleACS chemical biology2020

Multi-Institution Research and Education Collaboration Identifies New Antimicrobial Compounds.

Amelia A Fuller, Amy B Dounay, Douglas Schirch, Daniel G Rivera, Karl A Hansford, Alysha G Elliott, Johannes Zuegg, Matthew A Cooper, Mark A T Blaskovich, Jacob R Hitchens and 6 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Antibiotics (Basel, Switzerland) · 2025
    Review
  4. Proline-Modified (RW)ACS omega · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Amelia A FullerSanta Clara University, Department of Chemistry & Biochemistry, Santa Clara, California 95053, United States.ORCID 0000-0002-9291-6037
Amy B DounayDepartment of Chemistry and Biochemistry, Colorado College, 14 E. Cache La Poudre Street, Colorado Springs, Colorado 80903, United States.ORCID 0000-0003-0451-5549
Douglas SchirchDepartment of Chemistry, Goshen College, 1700 South Main Street, Goshen, Indiana 46526, United States.
Daniel G RiveraCenter for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana, Cuba.ORCID 0000-0002-5538-1555
Karl A HansfordCommunity for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID 0000-0003-2535-9071
Alysha G ElliottCommunity for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID 0000-0002-2983-0484
Johannes ZueggCommunity for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Matthew A CooperCommunity for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.ORCID 0000-0003-3147-3460
Mark A T BlaskovichCommunity for Open Antimicrobial Drug Discovery, Centre for Superbug Solutions, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland 4072, Australia.
Jacob R HitchensDepartment of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford Street, Indianapolis, Indiana 46202, United States.
Sarah Burris-HidayDepartment of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford Street, Indianapolis, Indiana 46202, United States.
Kristiana TenorioSanta Clara University, Department of Chemistry & Biochemistry, Santa Clara, California 95053, United States.
Yanira MendezCenter for Natural Products Research, Faculty of Chemistry, University of Havana, Zapata y G, 10400, La Habana, Cuba.ORCID 0000-0003-2124-4912
J Geno SamaritoniDepartment of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford Street, Indianapolis, Indiana 46202, United States.
Martin J O'DonnellDepartment of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford Street, Indianapolis, Indiana 46202, United States.
William L ScottDepartment of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N. Blackford Street, Indianapolis, Indiana 46202, United States.
Indiana University – Purdue University Indianapolis · USThe University of Queensland · AUSanta Clara University · USUniversity of Havana · CUColorado College · USGoshen College · US

Funding

SCHIFF BASE SYNTHONS IN AMINO ACID CHEMISTRYR01GM028193 · NIGMS · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI O'DONNELL, MARTIN JAMES · 1985 to 2006
$815k
NIGMS NIH HHS R01 GM028193Wellcome Trust
6 · The paper itself

Abstract

New antibiotics are urgently needed to address increasing rates of multidrug resistant infections. Seventy-six diversely functionalized compounds, comprising five structural scaffolds, were synthesized and tested for their ability to inhibit microbial growth. Twenty-six compounds showed activity in the primary phenotypic screen at the Community for Open Antimicrobial Drug Discovery (CO-ADD). Follow-up testing of active molecules confirmed that two unnatural dipeptides inhibit the growth of

Indexed as

Interinstitutional RelationsOrganizational AffiliationAnti-Infective AgentsEducationHumansMicrobial Sensitivity TestsReproducibility of ResultsAnti-Infective Agents

Identifiers

PMID33242957
PMCPMC7928911
OpenAlexW3108644662

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.