ArticleProgress in neurobiology2021
The environmental sculpting hypothesis of juvenile and adult hippocampal neurogenesis.
Article in Progress in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Maternal Isocaloric Monosaccharide Diets Reorganize Dorsal-Ventral Hippocampal Maturation and Ventral Plasticity in Rat Offspring.Cellular and molecular neurobiology · 2026Article
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- Review
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- Adult neurogenesis and "immature" neurons in mammals: an evolutionary trade-off in plasticity?Brain structure & function · 2024Review
- Memory circuits in dementia: The engram, hippocampal neurogenesis and Alzheimer's disease.Progress in neurobiology · 2024Review
- T-Type CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis.Frontiers in neuroscience · 2024Article
- Neuron and Brain Maturation 2.0.International journal of molecular sciences · 2023Article
- Neurotrophic factor-based pharmacological approaches in neurological disorders.Neural regeneration research · 2023Review
- Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice.Communications biology · 2023Article
- Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval.Scientific reports · 2022Article
- Review
- Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions.International journal of molecular sciences · 2021Review
- Prolonged development of long-term potentiation at lateral entorhinal cortex synapses onto adult-born neurons.PloS one · 2021Article
- Social Regulation of Negative Valence Systems During Development.Frontiers in systems neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We propose that a major contribution of juvenile and adult hippocampal neurogenesis is to allow behavioral experience to sculpt dentate gyrus connectivity such that sensory attributes that are relevant to the animal's environment are more strongly represented. This "specialized" dentate is then able to store a larger number of discriminable memory representations. Our hypothesis builds on accumulating evidence that neurogenesis declines to low levels prior to adulthood in many species. Rather than being necessary for ongoing hippocampal function, as several current theories posit, we argue that neurogenesis has primarily a prospective function, in that it allows experience to shape hippocampal circuits and optimize them for future learning in the particular environment in which the animal lives. Using an anatomically-based simulation of the hippocampus (BACON), we demonstrate that environmental sculpting of this kind would reduce overlap among hippocampal memory representations and provide representation cells with more information about an animal's current situation; consequently, it would allow more memories to be stored and accurately recalled without significant interference. We describe several new, testable predictions generated by the sculpting hypothesis and evaluate the hypothesis with respect to existing evidence. We argue that the sculpting hypothesis provides a strong rationale for why juvenile and adult neurogenesis occurs specifically in the dentate gyrus and why it declines significantly prior to adulthood.
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