Evidence map›Paper›PMID 33242529›Full record

ReviewJournal of neuroscience methods2021

Gradient waveform design for tensor-valued encoding in diffusion MRI.

Filip Szczepankiewicz, Carl-Fredrik Westin, Markus Nilsson

Abstract readReview
In one paragraph

Review in Journal of neuroscience methods, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Human In Vivo Validation of Frequency-Dependent QTI.Magnetic resonance in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Filip SzczepankiewiczRadiology, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States; Clinical Sciences, Lund University, Lund, Sweden. Electronic address: filip.szczepankiewicz@med.lu.se.
Carl-Fredrik WestinRadiology, Brigham and Women's Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.
Markus NilssonClinical Sciences, Lund University, Lund, Sweden.

Funding

Training and DisseminationP41EB015902 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI KIKINIS, RON, WESTIN, CARL-FREDRIK · 2012 to 2022
$20.9M
Novel DT-MRI Analyses of White Matter in SchizophreniaR01MH074794 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI WESTIN, CARL-FREDRIK · 2007 to 2021
$9.6M
NIBIB NIH HHS P41 EB015902NIMH NIH HHS R01 MH074794
6 · The paper itself

Abstract

Diffusion encoding along multiple spatial directions per signal acquisition can be described in terms of a b-tensor. The benefit of tensor-valued diffusion encoding is that it unlocks the 'shape of the b-tensor' as a new encoding dimension. By modulating the b-tensor shape, we can control the sensitivity to microscopic diffusion anisotropy which can be used as a contrast mechanism; a feature that is inaccessible by conventional diffusion encoding. Since imaging methods based on tensor-valued diffusion encoding are finding an increasing number of applications we are prompted to highlight the challenge of designing the optimal gradient waveforms for any given application. In this review, we first establish the basic design objectives in creating field gradient waveforms for tensor-valued diffusion MRI. We also survey additional design considerations related to limitations imposed by hardware and physiology, potential confounding effects that cannot be captured by the b-tensor, and artifacts related to the diffusion encoding waveform. Throughout, we discuss the expected compromises and tradeoffs with an aim to establish a more complete understanding of gradient waveform design and its impact on accurate measurements and interpretations of data.

Indexed as

Diffusion Magnetic Resonance ImagingDiffusion Tensor ImagingAnisotropyArtifactsDiffusionDiffusion magnetic resonance imagingGradient waveform designTensor-valued diffusion encoding

Identifiers

PMID33242529
PMCPMC8443151

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.