ArticleThe Journal of pediatrics2021
Obesity at Age 6 Months Is Associated with Shorter Preschool Leukocyte Telomere Length Independent of Parental Telomere Length.
Article in The Journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- The Impact of Foods, Nutrients, or Dietary Patterns on Telomere Length in Childhood and Adolescence: A Systematic Review.Nutrients · 2022Pooled it
- Nonlinear association between body mass index, perceived discrimination, and psychological sub-health problems among adolescents: risks of undernutrition versus overnutrition.BMC psychology · 2026Article
- Maternal hypertension and telomere length are associated with weight for age Z score change from birth to 6 months of age in a predominantly Latinx cohort.BMC pregnancy and childbirth · 2025Article
- Leukocyte telomere length and birth characteristics associated with obesity in infancy in a predominantly Latinx cohort.Pediatric obesity · 2025Article
- Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children.Maternal health, neonatology and perinatology · 2025Article
- Prenatal per- and polyfluoroalkyl substance mixtures and weight for length from birth to 12 months: The New Hampshire Birth Cohort Study.The Science of the total environment · 2025Article
- Food insecurity is a risk factor for metabolic dysfunction-associated steatotic liver disease in Latinx children.Pediatric obesity · 2024Article
- Association Between Adverse Early Life Factors and Telomere Length in Middle and Late Life.Innovation in aging · 2024Article
- Sub-optimal maternal gestational gain is associated with shorter leukocyte telomere length at birth in a predominantly Latinx cohort of newborns.Maternal health, neonatology and perinatology · 2023Article
- The interaction of socioeconomic stress and race on telomere length in children: A systematic review and meta-analysis.SSM - population health · 2023Article
- Associations of cord blood leukocyte telomere length with adiposity growth from infancy to adolescence.Pediatric obesity · 2023Article
- Longitudinal Association of Telomere Dynamics with Obesity and Metabolic Disorders in Young Children.Nutrients · 2022Article
- Prenatal exposure to maternal psychological distress and telomere length in childhood.Developmental psychobiology · 2022Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo assess whether early modifiable dietary factors and obesity measures are associated with leukocyte telomere length at 3-5 years of age after controlling for the heritability of leukocyte telomere length in a prospective cohort of low-income Latina mothers and their children in San Francisco. STUDY
designWe analyzed data from the Latinx, Eating and Diabetes cohort, a prospective study of 97 woman-infant dyads. We used linear regression models to evaluate associations between early dietary factors and obesity measures and child leukocyte telomere length at 3-5 years of age. Multivariable models included child age at the time of telomere collection, breastfeeding at 6 months (yes/no), obesity at 6 months, maternal education, child sex, and maternal and paternal leukocyte telomere length.
resultsData for 73 of the 97 children at 3-5 years of age were analyzed. Any breastfeeding at 6 months was positively associated (β = 0.14; P = .02) and obesity at 6 months was negatively associated (β = -0.21; P < .001) with leukocyte telomere length in bivariate analyses. In multivariable models including parental leukocyte telomere length, obesity at 6 months was associated with a shorter leukocyte telomere length at 3-5 years of age (β = -0.15; P = .02). Analyses of dietary factors showed high flavored milk consumption at 3 years of age was associated with shorter leukocyte telomere length after adjustment for possible confounders.
conclusionsIn a low-income Latinx population, obesity at 6 months of age is negatively associated with cellular health at 3-5 years of age after controlling for genetic factors (parental leukocyte telomere length) associated with leukocyte telomere length. Early life obesity may be more deleterious for cellular health than obesity later in childhood.
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