ReviewCell2020
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration.
Erratum issued Registry-linked trialAbstract readReview
In one paragraph
Review in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04856410 (Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions), which is not on this map. Cited by 214 papers.
0numbers the graph read from it
0cells of the map it votes in
214citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT04856410 naenrolling by invitationnot on this mapstarted 2021, after this paper: background citation
Temporal Nature of Cognitive and Visuospatial Brain Domain Changes During Long-Duration Low-Earth Orbit Missions (Spatial Cognition)
Who cites it
214 citing papers in PubMed.
- Printing knowledge in microgravity: PULSE and the education needed for space biomedicine.Experimental physiology · 2026Article
- Proton Radiation-Induced Cognitive Impairment via Disruption of Hippocampal Neuronal Mitophagic Homeostasis.Biomolecules · 2026Article
- Personalization and Fortification of In-Space Manufactured Emulsified Beverages for Long-Term Space Travel.Comprehensive reviews in food science and food safety · 2026Review
- A Ternary Flavonoid Formulation Mitigates Fractional Radiation-Induced Brain Injury via Transcriptomic Reprogramming and Synaptic Protection.International journal of molecular sciences · 2026Article
- Beyond Earth: Recent Advancements in Microgravity Biomedical and Genetic Research in Saudi Arabia.International journal of molecular sciences · 2026Review
- ibSLS as a biobank for democratizing access to multi-omics data and biospecimens from spaceflight research.Nature communications · 2026Article
- From Collapse to Active Self-Repair: Integrative Multi-Omics and Machine Learning Analysis Map the Hepatic Metabolic Adaption in Response to Simulated Spaceflight Stress.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.Communications biology · 2026Review
- Spaceflight multi-omics reveals vulnerabilities of human germ cell development.Science advances · 2026Article
- Automated behavioral segmentation and markerless pose tracking of mice during spaceflight.bioRxiv : the preprint server for biology · 2026Article
- Gravitational and mechanical forces shape mitochondrial translation.Nature communications · 2026Article
- Longitudinal metabolomics profiles reveal increased gut microbial protein fermentation during Spaceflight.Nature communications · 2026Article
- Modular lab-on-chip platform with integrated a-Si:H sensors for real-time bioluminescence monitoring in bioreactors under microgravity conditions.Scientific reports · 2026Article
- Multiomics analysis of the molecular and single-cell responses of rice after deep-space flight on Chang'e-5.Nature communications · 2026Article
- The effect of two different defatted insect meals in Japanese quail diets on the performance, ileal morphometry, apparent ileal digestibility and blood parameters.Poultry science · 2026Article
- Understanding Spaceflight-Induced Oxidative Stress and the Critical Role of Diet and Microbiome.Antioxidants (Basel, Switzerland) · 2026Review
- Article
- Formulation of Personalized, Fortified Beverage Nanoemulsions for Space Exploration with Omega‑3 Polyunsaturated Fatty Acids.ACS food science & technology · 2026Article
- The case for space as a model of accelerated aging.Nature aging · 2026Review
- Integrative bioinformatics analysis of potential convergent evolution in tardigrade stress-response proteins.Stress biology · 2026Article
154 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
38 authors.
Ebrahim AfshinnekooDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
Ryan T ScottKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Matthew J MacKayDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
Eloise ParisetUniversities Space Research Association (USRA), Mountain View, CA 94043, USA; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Egle CekanaviciuteSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Richard BarkerDepartment of Botany, University of Wisconsin, Madison, WI 53706, USA.
Simon GilroyDepartment of Botany, University of Wisconsin, Madison, WI 53706, USA.
Duane HassaneTempus Labs, Inc., Chicago, IL 60654, USA.
Scott M SmithHuman Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
Sara R ZwartDepartment of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA.
Mayra Nelman-GonzalezKBR, Human Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
Brian E CrucianHuman Health and Performance Directorate, NASA Johnson Space Center, Houston, TX 77058, USA.
Sergey A PonomarevInstitute for the Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia.
Oleg I OrlovInstitute for the Biomedical Problems, Russian Academy of Sciences, 123007 Moscow, Russia.
Dai ShibaJEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Ibaraki 305-8505, Japan.
Masafumi MurataniTransborder Medical Research Center, and Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Masayuki YamamotoDepartment of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8573, Japan.
Stephanie E RichardsBionetics, NASA Kennedy Space Center, Kennedy Space Center, Merritt Island, FL 32899, USA.
Parag A VaishampayanSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
Jonathan FooxDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA.
Jacqueline MyrrheEuropean Space Agency, Research and Payloads Group, Data Exploitation and Utilisation Strategy Office, 2200 AG Noordwijk, the Netherlands.
Eric IstasseEuropean Space Agency, Research and Payloads Group, Data Exploitation and Utilisation Strategy Office, 2200 AG Noordwijk, the Netherlands.
Nitin SinghBiotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.
Kasthuri VenkateswaranBiotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA.
Jessica A KeuneSpace Medicine Operations Division, NASA Johnson Space Center, Houston, TX 77058, USA.
Hami E RayASRC Federal Space and Defense, Inc., Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Mathias BasnerDepartment of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Jack MillerKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Martha Hotz VitaternaCenter for Sleep and Circadian Biology, Northwestern University, Evanston, IL 60208, USA; Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.
Deanne M TaylorDepartment of Biomedical Informatics, The Children's Hospital of Philadelphia, PA 19104, USA; Center for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Douglas WallaceCenter for Mitochondrial and Epigenomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; The Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kathleen RubinsAstronaut Office, NASA Johnson Space Center, Houston, TX 77058, USA.
Susan M BaileyDepartment of Environmental & Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: susan.bailey@colostate.edu.
Peter GrabhamCenter for Radiological Research, Department of Oncology, College of Physicians and Surgeons, Columbia University, New York, NY 10027, USA. Electronic address: pwg2@cumc.columbia.edu.
Sylvain V CostesSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA. Electronic address: sylvain.v.costes@nasa.gov.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10021, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY 10021, USA; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, NY 10021, USA. Electronic address: chm2042@med.cornell.edu.
Afshin BeheshtiKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: afshin.beheshti@nasa.gov.
Funding
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5MMetagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4MThe Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3MNASA NNX14AB02GNASA NNX14AH51GNCI NIH HHS R01 CA249054NIAID NIH HHS R01 AI151059NIMH NIH HHS R01 MH117406Shared Services Center NASA 80NSSC19K0434
Abstract
Research on astronaut health and model organisms have revealed six features of spaceflight biology that guide our current understanding of fundamental molecular changes that occur during space travel. The features include oxidative stress, DNA damage, mitochondrial dysregulation, epigenetic changes (including gene regulation), telomere length alterations, and microbiome shifts. Here we review the known hazards of human spaceflight, how spaceflight affects living systems through these six fundamental features, and the associated health risks of space exploration. We also discuss the essential issues related to the health and safety of astronauts involved in future missions, especially planned long-duration and Martian missions.
Indexed as
Extraterrestrial EnvironmentSpace FlightAstronautsHealthHumansMicrobiotaRisk Factorsaerospace medicineDNA damageepigeneticmicrobiomemitochondriamulti-omicsoxidative stressspace biologyspaceflighttelomere
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Read underepoch 390
Registered trials
NCT04856410ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.