ArticleCell reports2020
Circulating miRNA Spaceflight Signature Reveals Targets for Countermeasure Development.
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Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
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39 citing papers in PubMed.
- Collagen-heparan sulfate microcarriers support mesenchymal stem cell culture in microgravity and streamline post-flight recovery.NPJ microgravity · 2026Article
- Space radiation and microgravity as models of accelerated aging: modulation of hepatic miRNA-TGF-β networks associated with senescence and fibrosis.GeroScience · 2026Article
- Extracellular vesicle transcriptomic analysis to investigate muscle adaptation in microgravity.iScience · 2026Article
- Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.Nature reviews. Immunology · 2026Review
- A systematic review of microgravity on reproductive systems: Implications for space biology and human health.iScience · 2026Review
- MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways.Nature communications · 2026Article
- The hierarchical stratum response system of organism to microgravity during spaceflight.Military Medical Research · 2026Review
- An Update on Neuroaging on Earth and in Spaceflight.International journal of molecular sciences · 2025Review
- Carotid wall structure during and after 6 months of spaceflight.Frontiers in physiology · 2025Article
- To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants.Communications biology · 2024Article
- Omics Studies of Specialized Cells and Stem Cells under Microgravity Conditions.International journal of molecular sciences · 2024Review
- Differential network analysis reveals the key role of the ECM-receptor pathway inMolecular therapy. Nucleic acids · 2024Article
- Dermatologic Considerations for Spaceflight and Space Exploration.JID innovations : skin science from molecules to population health · 2024Article
- The Untapped Biomarker Potential of MicroRNAs for Health Risk-Benefit Analysis of Vaping vs. Smoking.Cells · 2024Review
- Review
- Space radiation damage rescued by inhibition of key spaceflight associated miRNAs.Nature communications · 2024Article
- Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).Nature communications · 2024Article
- Aging and putative frailty biomarkers are altered by spaceflight.Scientific reports · 2024Article
- Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.Nature communications · 2024Article
- Influence of the spaceflight environment on macrophage lineages.NPJ microgravity · 2024Review
Corrections and comments
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Authors and funding
35 authors.
Sherina MalkaniBlue Marble Space Institute of Science, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Christopher R ChinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Egle CekanaviciuteSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Marie MortreuxDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Hazeem OkinulaCenter for Radiological Research, Columbia University, New York, NY 10032, USA.
Marcel TarbierScience for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Ann-Sofie SchreursKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Yasaman Shirazi-FardSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Candice G T TahimicKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Deyra N RodriguezNew England Biolabs, Ipswich, MA, USA.
Brittany S SextonNew England Biolabs, Ipswich, MA, USA.
Daniel ButlerDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Akanksha VermaDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Daniela BezdanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA; Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tubingen, Germany.
Ceyda DurmazDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Matthew MacKayDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Ari MelnickDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA.
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.
Sheng LiThe Jackson Laboratories, Farmington, CT, USA.
Francine Garrett-BakelmanDepartment of Medicine, Weill Cornell Medicine, New York, NY, USA; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Bastian FrommScience for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Ebrahim AfshinnekooDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Brad W LanghorstNew England Biolabs, Ipswich, MA, USA.
Eileen T DimalantaNew England Biolabs, Ipswich, MA, USA.
Margareth Cheng-CampbellCenter for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Elizabeth BlaberCenter for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA; Universities Space Research Association, Space Biosciences Division, NASA Ames Research Center, Mountain View, CA 94035, USA.
Jonathan C SchislerMcAllister Heart Institute, Department of Pharmacology, and Department of Pathology and Lab Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Charles VanderburgStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Marc R FriedländerScience for Life Laboratory, Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
J Tyson McDonaldDepartment of Radiation Medicine, Georgetown University School of Medicine, Washington DC 20007, USA.
Sylvain V CostesSpace Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA.
Seward RutkoveDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Peter GrabhamCenter for Radiological Research, Columbia University, New York, NY 10032, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. Electronic address: chm2042@med.cornell.edu.
Afshin BeheshtiKBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94035, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: afshin.beheshti@nasa.gov.
Funding
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5MThe Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3MDual CHIP Functions Control Tau Triage In Alzheimer's DiseaseR01AG061188 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COHEN, TODD JONATHAN, SCHISLER, JONATHAN C. · 2019 to 2023
$3.1MProtein quality control in age-related diseasesR01AG066710 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHISLER, JONATHAN C. · 2020 to 2024
$2.4MNCI NIH HHS R01 CA249054NIA NIH HHS R01 AG066710NIMH NIH HHS R01 MH117406
Abstract
We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated, short-duration and long-duration spaceflight. Previous studies have identified miRNAs that regulate rodent responses to spaceflight in low-Earth orbit, and we have confirmed the expression of these proposed spaceflight-associated miRNAs in rodents reacting to simulated spaceflight conditions. Moreover, astronaut samples from the NASA Twins Study confirmed these expression signatures in miRNA sequencing, single-cell RNA sequencing (scRNA-seq), and single-cell assay for transposase accessible chromatin (scATAC-seq) data. Additionally, a subset of these miRNAs (miR-125, miR-16, and let-7a) was found to regulate vascular damage caused by simulated deep space radiation. To demonstrate the physiological relevance of key spaceflight-associated miRNAs, we utilized antagomirs to inhibit their expression and successfully rescue simulated deep-space-radiation-mediated damage in human 3D vascular constructs.
Indexed as
AnimalsCirculating MicroRNAFemaleGene ExpressionGene Expression ProfilingHumansMaleMiceMice, Inbred BALB CMicroRNAsMiddle AgedRatsSequence Analysis, RNASpace FlightTranscriptomeWeightlessnessCirculating MicroRNAMicroRNAsantagomirsmicrogravitymicroRNAmiRNA-seqNASAscATAC-seqscRNA-seqspaceflightspace radiationTwins Study
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