Evidence map›Paper›PMID 33242405›Full record

ArticleCell reports2020

Clonal Hematopoiesis Before, During, and After Human Spaceflight.

Nuria Mencia-Trinchant, Matthew J MacKay, Christopher Chin, Ebrahim Afshinnekoo, Jonathan Foox, Cem Meydan, Daniel Butler, Christopher Mozsary, Nicholas A Vernice, Charlotte Darby and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
  2. Clonal Hematopoiesis of Indeterminate Potential After Radiation Therapy.International journal of radiation oncology, biology, physics · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Modeling the Effects of Protracted Cosmic Radiation in a Human Organ-on-Chip Platform.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
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  16. Review
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  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Nuria Mencia-TrinchantWeill Cornell Medicine, New York, NY, USA.
Matthew J MacKayDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA.
Christopher ChinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Ebrahim AfshinnekooDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA.
Jonathan FooxDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA.
Daniel ButlerDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Christopher MozsaryDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Nicholas A VerniceDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA.
Charlotte DarbyJohns Hopkins University, Baltimore, MD, USA.
Michael C SchatzJohns Hopkins University, Baltimore, MD, USA.
Susan M BaileyUniversity of Colorado, Boulder, CO, USA.
Ari M MelnickWeill Cornell Medicine, New York, NY, USA.
Monica L GuzmanWeill Cornell Medicine, New York, NY, USA.
Kelly BoltonMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Lior Z BraunsteinMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Francine Garrett-BakelmanDepartment of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA, USA; University of Virginia Cancer Center, Charlottesville, VA, USA; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Ross L LevineJohns Hopkins University, Baltimore, MD, USA.
Duane C HassaneWeill Cornell Medicine, New York, NY, USA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; Tempus Labs Inc. Chicago, IL, USA. Electronic address: duane.hassane@gmail.com.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, 10065, USA; The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, New York, NY, USA; The WorldQuant Initiative for Quantitative Prediction, New York, NY, USA; The Feil Family Brain and Mind Research Institute, New York, NY, USA. Electronic address: chm2042@med.cornell.edu.
Cornell University · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · USUniversity of Colorado Boulder · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Clinical and Molecular Heterogeneity in the Myelodysplastic SyndromesR01CA249054 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MASON, CHRISTOPHER EDWARD, PARK, CHRISTOPHER Y · 2020 to 2024
$3.5M
Metagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4M
Defining molecular biomarkers for CDK4/6-based cancer therapy by RNA sequencingR21CA176362 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN-KIANG, SELINA Y, MASON, CHRISTOPHER EDWARD · 2013 to 2014
$399k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA249054NCI NIH HHS R21 CA176362NIAID NIH HHS R01 AI151059
6 · The paper itself

Abstract

Clonal hematopoiesis (CH) occurs when blood cells harboring an advantageous mutation propagate faster than others. These mutations confer a risk for hematological cancers and cardiovascular disease. Here, we analyze CH in blood samples from a pair of twin astronauts over 4 years in bulk and fractionated cell populations using a targeted CH panel, linked-read whole-genome sequencing, and deep RNA sequencing. We show CH with distinct mutational profiles and increasing allelic fraction that includes a high-risk, TET2 clone in one subject and two DNMT3A mutations on distinct alleles in the other twin. These astronauts exhibit CH almost two decades prior to the mean age at which it is typically detected and show larger shifts in clone size than age-matched controls or radiotherapy patients, based on a longitudinal cohort of 157 cancer patients. As such, longitudinal monitoring of CH may serve as an important metric for overall cancer and cardiovascular risk in astronauts.

Indexed as

AdultAstronautsClonal HematopoiesisClone CellsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHematologic NeoplasmsHematopoiesisHumansMaleMiddle AgedMutationNeoplasmsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanTET2 protein, humanastronautCHIPclonal hematopoiesisDNMT3ANASAradiationTET2variant allele frequency

Identifiers

PMID33242405
PMCPMC9398182
OpenAlexW3107075271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.