Evidence map›Paper›PMID 33242385›Full record

ReviewExpert review of gastroenterology & hepatology2021

Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity.

David S Umbaugh, Hartmut Jaeschke

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of gastroenterology & hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. The p21Toxicology · 2024
    Article
  7. Review
  8. Modulation of Hepatic Functions by Chicory (Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  9. Assessing Platelet Mitochondrial Dysfunction in a Murine Model of Acute Acetaminophen Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Mitochondrial Dysfunction and Chronic Liver Disease.Current issues in molecular biology · 2022
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David S UmbaughDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Hartmut JaeschkeDepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.ORCID https://orcid.org/0000-0002-8695-6980
University of Kansas Medical Center · US

Funding

Nuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1M
Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5M
Autophagy and Drug-Induced Liver InjuryR01DK102142 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING, JAESCHKE, HARTMUT W. · 2014 to 2022
$2.7M
Mitochondrial Dysfunction and Drug HepatotoxicityR01DK070195 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2005 to 2010
$1.8M
NIDDK NIH HHS R01 DK070195NIDDK NIH HHS R01 DK102142NIGMS NIH HHS P20 GM103549NIGMS NIH HHS P30 GM118247
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcetaminophenAnalgesics, Non-NarcoticAnimalsBiomarkersChemical and Drug Induced Liver InjuryHumansLiverLiver Function TestsLiver RegenerationMachine LearningMitochondria, LiverPredictive Value of TestsAcetaminophenAnalgesics, Non-NarcoticBiomarkersacetaminophenBiomarkercytokeratin-18drug-induced liver injuryextracellular vesiclesmachine learningmacrophage colony-stimulating factor receptorosteopontin

Identifiers

PMID33242385
PMCPMC8026489
OpenAlexW3109253825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.