ArticleThe British journal of radiology2021
Diagnostic accuracy of contrast-enhanced digital mammography in breast cancer detection in comparison to tomosynthesis, synthetic 2D mammography and tomosynthesis combined with ultrasound in women with dense breast.
Article in The British journal of radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Diagnostic performance of contrast-enhanced mammography for suspicious findings in dense breasts: A systematic review and meta-analysis.Cancer medicine · 2024Pooled it
- Comparison of Diagnostic Test Accuracy of Cone-Beam Breast Computed Tomography and Digital Breast Tomosynthesis for Breast Cancer: A Systematic Review and Meta-Analysis Approach.Sensors (Basel, Switzerland) · 2022Pooled it
- Fewer breast cancers during post-treatment surveillance among patients initially staged using contrast-based imaging.Breast cancer research and treatment · 2026Article
- Additional ultrasound in women with dense breasts in a breast cancer-screening program based on digital breast tomosynthesis: evidences on cancer detection, false positives and associated costs.Journal of ultrasound · 2026Article
- Diagnostic value of contrast-enhanced spectral mammography for breast lesions: qualitative and quantitative analyses.Quantitative imaging in medicine and surgery · 2026Article
- Article
- Contrast-Enhanced Mammography-Guided Biopsy in Patients with Extensive Suspicious Microcalcifications.Cancers · 2025Article
- Comparative Diagnostic Efficacy of Four Breast Imaging Modalities in Dense Breasts: A Single-Center Retrospective Study.Biomedicines · 2025Article
- AI image analysis as the basis for risk-stratified screening.Japanese journal of radiology · 2025Review
- Comparison of Contrast-enhanced Mammography and Low-Energy Imaging with or without Supplemental Whole-Breast US in Breast Cancer Detection.Radiology · 2025Observational
- Does Contrast-Enhanced Mammography Outperform Digital Breast Tomosynthesis for Detection and Characterization of Breast Lesions or Vice Versa?Indian journal of surgical oncology · 2025Article
- Contrast-enhanced mammography in high-dense breasts: a narrative review.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Review
- Validation of Contrast-Enhanced Mammography as Breast Imaging Modality Compared to Standard Mammography and Digital Breast Tomosynthesis.Diagnostics (Basel, Switzerland) · 2024Article
- Breast masses with rim enhancement on contrast-enhanced mammography: morphological and enhancement features for diagnosis and differentiation of benign and malignant.The British journal of radiology · 2024Article
- State-of-the-art for contrast-enhanced mammography.The British journal of radiology · 2024Review
- Comparison of the effectiveness of contrast-enhanced mammography in detecting malignant lesions in patients with extremely dense breasts compared to the all-densities population.Polish journal of radiology · 2024Article
- Contrast-enhanced mammography in the assessment of residual disease after neoadjuvant treatment.Breast cancer research and treatment · 2023Article
- Comparative Study of Digital Breast Tomosynthesis (DBT) with and without Ultrasound versus Breast Magnetic Resonance Imaging (MRI) in Detecting Breast Lesion.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the diagnostic efficacy of contrast-enhanced digital mammography (CEDM) in breast cancer detection in comparison to synthetic two-dimensional mammography (s2D MG), digital breast tomosynthesis (DBT) alone and DBT supplemented with ultrasound examination in females with dense breast with histopathology as the gold-standard.
methodsIt was a prospective study, where consecutive females presenting to symptomatic breast clinic between April 2019 and June 2020 were evaluated with DBT. Females who were found to have heterogeneously dense (ACR type C) or extremely dense (ACR type D) breast composition detected on s2D MG were further evaluated with high-resolution breast ultrasound and thereafter with CEDM, but before the core biopsy or surgical excision, were included in the study. s2D MG was derived from post-processing reconstruction of DBT data set. Females with pregnancy, renal insufficiency or prior allergic reaction to iodinated contrast agent were excluded from the study. Image interpretation was done by two experienced breast radiologists and both were blinded to histological diagnosis.
resultsThis study included 166 breast lesions in130 patients with mean age of 45 ± 12 years (age range 24-72 years). There were 87 (52.4%) malignant and 79 (47.6%) benign lesions. The sensitivity of CEDM was 96.5%, significantly higher than synthetic 2D MG (75.6%,
conclusionCEDM is an accurate diagnostic technique for cancer detection in dense breast. CEDM allowed a significantly higher number of breast cancer detection than the s2D MG, DBT alone and DBT supplemented with ultrasonography in females with dense breast. ADVANCES IN KNOWLEDGE: CEDM is a promising novel technology with higher sensitivity and negative predictive value for breast cancer detection in females with dense breast in comparison to DBT alone or DBT supplemented with ultrasound.
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