ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021
False positive rates in positron emission tomography (PET) voxelwise analyses.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Building an open infrastructure for molecular neuroimaging: Standards and tools from the OpenNeuroPET initiative.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Review
- Building an open ecosystem for molecular neuroimaging: standards and tools from the OpenNeuroPET initiative.bioRxiv : the preprint server for biology · 2026Article
- A sensitivity analysis of preprocessing pipelines: Toward a solution for multiverse analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Serotonin 4 Receptor Brain Binding in Major Depressive Disorder and Association With Memory Dysfunction.JAMA psychiatry · 2023Article
- Reproducibility of findings in modern PET neuroimaging: insight from the NRM2018 grand challenge.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Neuroimaging statistical approaches for determining neural correlates of Alzheimer's disease via positron emission tomography imaging.Wiley interdisciplinary reviews. Computational statisticsArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Issues with inflated false positive rates (FPRs) in brain imaging have recently received significant attention. However, to what extent FPRs present a problem for voxelwise analyses of Positron Emission Tomography (PET) data remains unknown. In this work, we evaluate the FPR using real PET data under group assignments that should yield no significant results after correcting for multiple comparisons. We used data from 159 healthy participants, imaged with the serotonin transporter ([
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.