Evidence map›Paper›PMID 33241694›Full record

ArticleDrug delivery2020

Exenatide-loaded inside-porous poly(lactic-co-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics.

Junqiu Zhai, Zhanlun Ou, Liuting Zhong, Yu-E Wang, Li-Ping Cao, Shixia Guan

Abstract read
In one paragraph

Article in Drug delivery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junqiu ZhaiSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhanlun OuSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Liuting ZhongSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yu-E WangSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Li-Ping CaoShenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen, China.
Shixia GuanSchool of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The glucagon-like peptide-1 receptor agonist exenatide (EXT) is an effective treatment for type 2 diabetes. However, this peptide has a short biological half-life and the delayed release characteristic of current formulations limit its clinical application. Herein, we prepared EXT-loaded inside-porous poly(d,l-lactic-co-glycolic acid (PLGA) microspheres with outside layers (EXT-PMS) using a W

Indexed as

Drug Delivery SystemsAnimalsDelayed-Action PreparationsDiabetes Mellitus, Type 2Drug LiberationEmulsionsExenatideHypoglycemic AgentsInjections, SubcutaneousMaleMicrofluidic Analytical TechniquesMicrospheresParticle SizePolylactic Acid-Polyglycolic Acid CopolymerPorosityRatsDelayed-Action PreparationsEmulsionsExenatideHypoglycemic AgentsPolylactic Acid-Polyglycolic Acid CopolymerExenatideinside-porous microsphereslong-actingrelease behaviortype 2 diabetes

Identifiers

PMID33241694
PMCPMC7875555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.