Evidence map›Paper›PMID 33241667›Full record

ArticleAdvanced healthcare materials2021

T Cell-Mediated Transport of Polymer Nanoparticles across the Blood-Brain Barrier.

Maxime Ayer, Markus Schuster, Isabelle Gruber, Claudia Blatti, Elisa Kaba, Gaby Enzmann, Olivier Burri, Romain Guiet, Arne Seitz, Britta Engelhardt and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Advanced healthcare materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 67 citations in OpenAlex.

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  12. Cell-drug conjugates.Nature biomedical engineering · 2024
    Review
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  15. Nonviral nanoparticle gene delivery into the CNS for neurological disorders and brain cancer applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2023
    Review
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  20. Advances in the research of nano delivery systems in ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Maxime AyerÉcole Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland.
Markus SchusterÉcole Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland.
Isabelle GruberTheodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Claudia BlattiTheodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Elisa KabaTheodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Gaby EnzmannTheodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Olivier BurriÉcole Polytechnique Fédérale de Lausanne (EPFL), Faculté des sciences de la vie, Bioimaging and Optics Platform, Bâtiment AI, Station 15, Lausanne, CH-1015, Switzerland.
Romain GuietÉcole Polytechnique Fédérale de Lausanne (EPFL), Faculté des sciences de la vie, Bioimaging and Optics Platform, Bâtiment AI, Station 15, Lausanne, CH-1015, Switzerland.
Arne SeitzÉcole Polytechnique Fédérale de Lausanne (EPFL), Faculté des sciences de la vie, Bioimaging and Optics Platform, Bâtiment AI, Station 15, Lausanne, CH-1015, Switzerland.
Britta EngelhardtTheodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, CH-3012, Switzerland.
Harm-Anton KlokÉcole Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères, Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland.ORCID 0000-0003-3365-6543
École Polytechnique Fédérale de Lausanne · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delivery of therapeutics to the central nervous system (CNS) is challenging due to the presence of the blood-brain barrier (BBB). Amongst various approaches that have been explored to facilitate drug delivery to the CNS, the use of cells that have the intrinsic ability to cross the BBB is relatively unexplored, yet very attractive. This paper presents a first proof-of-concept that demonstrates the feasibility of activated effector/memory CD4

Indexed as

Blood-Brain BarrierNanoparticlesAnimalsBiological TransportDrug Delivery SystemsMicePolymersT-LymphocytesPolymersblood-brain barrierscell-mediated deliveriescell-surface modificationsnanomedicinesnanoparticles

Identifiers

PMID33241667
PMCPMC11469241
OpenAlexW3110058846

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.