ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021
Regular physical activity postpones age of occurrence of first-ever stroke and improves long-term outcomes.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07569497 (Co-design of a Physical Activity Maintenance Intervention for People With Stroke), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Co-design of a Physical Activity Maintenance Intervention for People With Stroke
Who cites it
14 citing papers in PubMed.
- Moderate pre-stroke physical activity has a protective effect on symptoms of depression in the post-acute phase after stroke.Scientific reports · 2026Article
- Machine Learning Predictive Models for Survival in Patients with Brain Stroke.Health promotion perspectives · 2025Article
- Psychological Indices and Health-Related Quality of Life in Renal Replacement Therapy: A Three Groups Cross-Sectional Study.International journal of nephrology · 2025Article
- Prestroke Physical Activity Matters for Functional Limitations: A Longitudinal Case-Control Study of 12,860 Participants.Physical therapy · 2024Article
- Domain-Specific Physical Activity and Stroke in Sweden.JAMA network open · 2024Article
- Pre-stroke physical activity matters for functional limitations: A longitudinal case-control study of 12,860 participants.medRxiv : the preprint server for health sciences · 2024Article
- Psycho-Cardiological Disease in COVID-19 Era.Reviews in cardiovascular medicine · 2023Review
- Long-term consequences of COVID-19 on mental health and the impact of a physically active lifestyle: a narrative review.Annals of general psychiatry · 2023Review
- Transplantation of Exercise-Induced Extracellular Vesicles as a Promising Therapeutic Approach in Ischemic Stroke.Translational stroke research · 2023Review
- Associations of Prestroke Physical Activity With Stroke Severity and Mortality After Intracerebral Hemorrhage Compared With Ischemic Stroke.Neurology · 2022Article
- Stroke survivors with the same levels of exercise as healthy individuals have lower levels of physical activity.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Pre-stroke physical activity in relation to post-stroke outcomes - linked to the International Classification of Functioning, Disability and Health (ICF): A scoping review.Journal of rehabilitation medicine · 2022Article
- Elevated visceral adiposity index is associated with increased stroke prevalence and earlier age at first stroke onset: Based on a national cross-sectional study.Frontiers in endocrinology · 2022Article
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Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveFew data are available on the associations between the level of pre-stroke physical activity and long-term outcomes in patients with stroke. This study is designed to assess the associations between pre-stroke physical activity and age of first-ever stroke occurrence and long-term outcomes.
methodsSix hundred twenty-four cases with first-ever stroke were recruited from the Mashhad Stroke Incidence Study a prospective population-based cohort in Iran. Data on Physical Activity Level (PAL) were collected retrospectively and were available in 395 cases. According to the PAL values, subjects were classified as inactive (PAL < 1.70) and active (PAL ≥ 1.70). Age at onset of stroke was compared between active and inactive groups. Using logistic model, we assessed association between pre-stroke physical activity and long-term (5-year) mortality, recurrence, disability, and functional dependency rates. We used multiple imputation to analyze missing data.
resultsInactive patients (PAL < 1.70) were more than 6 years younger at their age of first-ever-stroke occurrence (60.7 ± 15.5) than active patients (67.0 ± 13.2; p < 0.001). Patients with PAL< 1.7 also had a greater risk of mortality at 1 year [adjusted odds ratio (aOR) = 2.31; 95%CI: 1.14-4.67, p = 0.02] and 5 years after stroke (aOR = 1.81; 95%CI: 1.05-3.14, p = 0.03) than patients who were more physically active. Recurrence rate, disability, and functional dependency were not statistically different between two groups. Missing data analysis also showed a higher odds of death at one and 5 years for inactive patients.
conclusionsIn our cohort, we observed a younger age of stroke and a higher odds of 1- and 5-year mortality among those with less physical activity. This is an important health promotion strategy to encourage people to remain physically active.
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