Evidence map›Paper›PMID 33241532›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Association between MMP16 rs60298754 and clinical phenotypes of Parkinson's disease in southern Chinese.

Kui Chen, Meng-Ruo Guo, Yue Zhang, Gang Li, Yi Liu, Bei Zhang

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kui Chen *Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Meng-Ruo Guo *Graduate School, Dalian Medical University, Dalian, Liaoning Province, 116044, China.
Yue Zhang *Department of Neurology, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
Gang LiDepartment of Neurology, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China.
Yi LiuDepartment of Neurology, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China. 13834681049@163.com.
Bei ZhangDepartment of Neurology, Shanghai East Hospital, Tongji University School of Medicine, 1800 Yuntai Road, Shanghai, 200123, China. zhangbei0227@163.com.ORCID http://orcid.org/0000-0002-5486-0941

Funding

Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai PWZxq2017-08National Natural Science Foundation of China 81601010National Natural Science Foundation of China 81701039National Natural Science Foundation of China 81870843the Outstanding Leaders Training Program of Pudong new area health system of Shanghai PWRl2018-01Young Excellent Talents in Tongji University 22120180604
6 · The paper itself

Abstract

STUDY

objectivesThe aim was to investigate the association between MMP16 rs60298754 and symptoms of Parkinson's disease (PD) in southern Chinese.

methodsSeven hundred forty-five PD patients were recruited in this study. All patients were evaluated by Brief Pain Inventory (BPI), Hamilton anxiety rating scale and Hamilton depression rating scale, 39-item Parkinson's disease Questionnaire (PDQ-39), and MDS-Unified PD Rating Scale (MDS-UPDRS). Symptoms were also recorded.

resultsThe difference of BPI and Parkinson's disease sleep scale (PDSS) between two groups was showed (BPI: MMP16 wildtypes: 14.73 ± 14.45; MMP16 carriers: 10.95 ± 10.67, p 0.002; PDSS: MMP16 wildtypes: 117.80 ± 21.45; MMP16 carriers: 108.40 ± 23.95, p < 0.001). The association of apathy, nocturia, and sensitive to light were found (apathy: p 0.001, OR: 0.49, 0.32-0.76; nocturia: p < 0.001, OR: 3.57, 1.90-7.26; sensitive to light: p < 0.001, OR: 3.99, 2.01-7.74).

conclusionsMMP16 rs60298754 was associated with the presence of apathy, pain, nocturia, and sensitive to light.

Indexed as

ApathyParkinson DiseaseChinaHumansMatrix Metalloproteinase 16PhenotypeMatrix Metalloproteinase 16MMP16 protein, humanApathyMMP16PainParkinson’s disease

Identifiers

PMID33241532

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.