Evidence map›Paper›PMID 33241508›Full record

ReviewReviews in endocrine & metabolic disorders2021

Impact of COVID-19 on the thyroid gland: an update.

Lorenzo Scappaticcio, Fabián Pitoia, Katherine Esposito, Arnoldo Piccardo, Pierpaolo Trimboli

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reviews in endocrine & metabolic disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 11 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 11 syntheses or guidelines pooled it, 263 citations in OpenAlex.

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  4. Pediatric endocrinopathies related to COVID-19: an update.World journal of pediatrics : WJP · 2023
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  11. Systematic review of COVID-19 and autoimmune thyroiditis.Travel medicine and infectious disease
    Pooled it
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  15. COVID-19 pandemic and thyroid diseases.Frontiers in endocrinology · 2026
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Lorenzo ScappaticcioDivision of Endocrinology and Metabolic Diseases, University Hospital "Luigi Vanvitelli", University of Campania "L. Vanvitelli", Naples, Italy.
Fabián PitoiaDivision of Endocrinology, Hospital de Clínicas, University of Buenos Aires, Buenos Aires, Argentina.
Katherine EspositoDepartment of Advanced Medical and Surgical Sciences, University of Campania "L. Vanvitelli", Naples, Italy.
Arnoldo PiccardoDepartment of Nuclear Medicine, Galliera Hospital, Genoa, Italy.
Pierpaolo TrimboliClinic of Endocrinology and Diabetology, Lugano and Mendrisio Regional Hospital, Ente Ospedaliero Cantonale, Bellinzona, Switzerland. pierpaolo.trimboli@eoc.ch.ORCID 0000-0002-2125-4937
University of Campania "Luigi Vanvitelli" · ITEnte Ospedaliero Cantonale · CHEnte Ospedaliero Ospedali Galliera · ITUniversidad de Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) is the pandemic of the new millennium. COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Data on the relationship between COVID-19 and thyroid have been emerging, and rapidly increasing since March 2020. The thyroid gland and the virus infection with its associated inflammatory-immune responses are known to be engaged in complex interplay. SARS-CoV-2 uses ACE2 combined with the transmembrane protease serine 2 (TMPRSS2) as the key molecular complex to infect the host cells. Interestingly, ACE2 and TMPRSS2 expression levels are high in the thyroid gland and more than in the lungs. Our literature search provided greater evidence that the thyroid gland and the entire hypothalamic-pituitary-thyroid (HPT) axis could be relevant targets of damage by SARS-CoV-2. Specifically, COVID-19-related thyroid disorders include thyrotoxicosis, hypothyroidism, as well as nonthyroidal illness syndrome. Moreover, we noticed that treatment plans for thyroid cancer are considerably changing in the direction of more teleconsultations and less diagnostic and therapeutical procedures. The current review includes findings that could be changed soon by new results on the topic, considering the rapidity of worldwide research on COVID-19.

Indexed as

COVID-19Thyroid DiseasesHumansPandemicsSARS-CoV-2COVID-19HyperthyroidismHypothyroidismThyroidThyroid cancer

Identifiers

PMID33241508
PMCPMC7688298
OpenAlexW3108425280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.