Evidence map›Paper›PMID 33241451›Full record

ArticleNeuroradiology2021

Surveillance imaging of grade 1 astrocytomas in children: can duration and frequency of follow-up imaging and the use of contrast agents be reduced?

Tom Campion, Bernadine Quirk, Jessica Cooper, Kim Phipps, Sebastian Toescu, Kristian Aquilina, Katherine Green, Darren Hargrave, Kshitij Mankad

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Tom CampionRadiology Department, Great Ormond Street Hospital, London, UK. thomascampion@nhs.net.ORCID http://orcid.org/0000-0003-0515-4925
Bernadine QuirkRadiology Department, Great Ormond Street Hospital, London, UK.
Jessica CooperRadiology Department, Great Ormond Street Hospital, London, UK.
Kim PhippsNeurosurgery Department, Great Ormond Street Hospital, London, UK.
Sebastian ToescuDevelopmental Neurosciences Department, Institute of Child Health, University College London, London, UK.
Kristian AquilinaNeurosurgery Department, Great Ormond Street Hospital, London, UK.
Katherine GreenHaematology and Oncology Department, Great Ormond Street Hospital, London, UK.
Darren HargraveHaematology and Oncology Department, Great Ormond Street Hospital, London, UK.
Kshitij MankadRadiology Department, Great Ormond Street Hospital, London, UK.
Great Ormond Street Hospital · GBUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe optimum strategy for the surveillance of low-grade gliomas in children has not been established, and there is concern about the use of gadolinium-based contrast agents (GBCAs), particularly in children, due to their deposition in the brain. The number of surveillance scans and the use of GBCAs in surveillance of low-risk tumours should ideally be limited. We aimed to investigate the consistency and utility of our surveillance imaging and also determine to what extent the use of GBCAs contributed to decisions to escalate treatment in children with grade 1 astrocytomas.

methodsThis was a retrospective single-centre study at a tertiary paediatric hospital. All children with a new diagnosis of a non-syndromic World Health Organization (WHO) grade 1 astrocytoma between 2007 and 2013 were included, with surveillance imaging up to December 2018 included in analysis. The intervals of surveillance imaging were recorded, and imaging and electronic health records were examined for decisions related to treatment escalation.

resultsEighty-eight patients had 690 surveillance scans in the study period. Thirty-one patients had recurrence or progression leading to treatment escalation, 30 of whom were identified on surveillance imaging. The use of GBCAs did not appear to contribute to multidisciplinary team (MDT) decisions in the majority of cases.

conclusionSurveillance imaging could be reduced in number and duration for completely resected cerebellar tumours. MDT decisions were rarely made on the basis of post-contrast imaging, and GBCA administration could therefore potentially be restricted in the setting of surveillance of grade 1 astrocytomas in children.

Indexed as

AstrocytomaContrast MediaChildFollow-Up StudiesHumansMagnetic Resonance ImagingNeoplasm Recurrence, LocalRetrospective StudiesContrast MediaAstrocytomaMagnetic resonance imagingPaediatricSurveillance

Identifiers

PMID33241451
PMCPMC7688203
OpenAlexW3108149772

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.