ArticleiScience2020
Radiation-Induced Damage to Prepubertal Pax7+ Skeletal Muscle Stem Cells Drives Lifelong Deficits in Myofiber Size and Nuclear Number.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cardiorespiratory fitness and physical performance after childhood hematopoietic stem cell transplantation: a systematic review and meta-analysis.Bone marrow transplantation · 2021Pooled it
- Irradiation of muscle precursor cells impairs the proliferative and angiogenic functions of their extracellular vesicles.Scientific reports · 2025Article
- Review
- Dynamic equilibrium of skeletal muscle macrophage ontogeny in the diaphragm during homeostasis, injury, and recovery.Scientific reports · 2024Article
- Control of muscle satellite cell function by specific exercise-induced cytokines and their applications in muscle maintenance.Journal of cachexia, sarcopenia and muscle · 2024Review
- Isolation, identification, and induced differentiation of satellite cells from skeletal muscle of adult tree shrews.In vitro cellular & developmental biology. Animal · 2024Article
- Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.Journal of cachexia, sarcopenia and muscle · 2023Article
- Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.NPJ microgravity · 2023Article
- Resistance and endurance exercise training improves muscle mass and the inflammatory/fibrotic transcriptome in a rhabdomyosarcoma model.Journal of cachexia, sarcopenia and muscle · 2023Article
- The myonuclear domain in adult skeletal muscle fibres: past, present and future.The Journal of physiology · 2023Review
- Physical Activity as the Best Supportive Care in Cancer: The Clinician's and the Researcher's Perspectives.Cancers · 2022Review
- Short-term and bystander effects of radiation on murine submandibular glands.Disease models & mechanisms · 2022Article
- Quantitative Evaluation of the Reduced Capacity of Skeletal Muscle Hypertrophy after Total Body Irradiation in Relation to Stem/Progenitor Cells.Journal of clinical medicine · 2022Article
- Insights into muscle stem cell dynamics during postnatal development.The FEBS journal · 2022Review
- Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress.Skeletal muscle · 2022Article
- The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Muscle-specific functional deficits and lifelong fibrosis in response to paediatric radiotherapy and tumour elimination.Journal of cachexia, sarcopenia and muscle · 2022Article
- Fusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Review
- Mouse models of sarcopenia: classification and evaluation.Journal of cachexia, sarcopenia and muscle · 2021Review
- Cryopreserved Stem Cells Incur Damages Due To Terrestrial Cosmic Rays Impairing Their Integrity Upon Long-Term Storage.Cell transplantationArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
During prepubertal development, muscle stem cells (satellite cells, SCs) actively contribute to myofiber growth. Because some SCs are active during this time, they may be particularly susceptible to damage. Using a Small Animal Radiation Research Platform (SARRP), we investigated the effects of local fractionated radiation treatment on prepubertal SCs. Immediately after this regimen, there was a reduction in SC number. Although surviving SCs had deficiencies in function, some myogenic potential remained. Indeed, some muscle regenerative capacity persisted immediately after irradiation. Lastly, we assessed the long-term consequences of radiation-induced SC loss during prepuberty. We observed a reduction of myofiber size and corresponding loss of nuclei in both fast- and slow-contracting muscles 14 months post-irradiation. Notably, prepubertal SC depletion mimicked these lifelong deficits. This work highlights the susceptibility of prepubertal SCs to radiation exposure. We also reveal the importance of prepubertal SC contribution to the lifelong maintenance of skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.