Evidence map›Paper›PMID 33240859›Full record

ReviewFrontiers in chemistry2020

Moving Beyond the Pillars of Cancer Treatment: Perspectives From Nanotechnology.

Cerise M Siamof, Shreya Goel, Weibo Cai

Abstract readReview
In one paragraph

Review in Frontiers in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Cationic mRNA Lipid Nanoparticles for Ex Vivo NanoCAR-T Cell Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Neutropenic events associated with new anticancer treatments, from pathophysiology to practice: a scoping review-NEW Group (Neutropenic Events Working Group).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Carbon Nanomaterials: Emerging Roles in Immuno-Oncology.International journal of molecular sciences · 2023
    Review
  13. DNA Damage and Its Role in Cancer Therapeutics.International journal of molecular sciences · 2023
    Review
  14. Review
  15. Irradiation immunity interactions.Journal of medical imaging and radiation oncology · 2022
    Review
  16. Article
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cerise M SiamofDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, United States.
Shreya GoelDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, United States.
Weibo CaiDepartment of Radiology, University of Wisconsin-Madison, Madison, WI, United States.

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
Ultrasound-Activated Piezoelectric P(VDF-TrFE) Nanoparticles for Electric Ablation of Cancer CellsR21EB027857 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO, WANG, XUDONG · 2019 to 2020
$413k
NCI NIH HHS P30 CA014520NIBIB NIH HHS R21 EB027857
6 · The paper itself

Abstract

Nanotechnology has made a significant impact on basic and clinical cancer research over the past two decades. Owing to multidisciplinary advances, cancer nanotechnology aims to address the problems in current cancer treatment paradigms, with the ultimate goal to improve treatment efficacy, increase patient survival, and decrease toxic side-effects. The potential for use of nanomedicine in cancer targeting and therapy has grown, and is now used to advance the four traditional pillars of cancer treatment: surgery, chemotherapy, radiation therapy and the newest pillar, immunotherapy. In this review we provide an overview of notable advances of nanomedicine in improving drug delivery, radiation therapy and immunotherapy. Potential barriers in the translation of nanomedicine from bench to bedside as well as strategies to overcome these barriers are also discussed. Promising preclinical findings highlight the translational and clinical potential of integrating nanotechnology approaches into cancer care.

Indexed as

drug deliveryimmunotherapynanomedcineradiation therapytheranosctics

Identifiers

PMID33240859
PMCPMC7683771

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.