Evidence map›Paper›PMID 33240707›Full record

ReviewCureus2020

Pacemaking Activity in the Peripheral Nervous System: Physiology and Roles of Hyperpolarization Activated and Cyclic Nucleotide-Gated Channels in Neuropathic Pain.

Fan Liu, George Y Wuni, Ronak Bahuva, Muhammad Ahsan Shafiq, Boula S Gattas, Crystal N Ibetoh, Eugeniu Stratulat, Domonick K Gordon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fan LiuInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
George Y WuniInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Ronak BahuvaInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Muhammad Ahsan ShafiqInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Boula S GattasInternal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Crystal N IbetohCardiology, Metropolitan Cardiovascular Consultants, Beltsville, USA.
Eugeniu StratulatObstetrics and Gynecology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Domonick K GordonInternal Medicine, Scarborough General Hospital, Scarborough, TTO.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most famous pacemaking activity found in the human body is in the cardiac system. However, pacemaking is also widely present in the nervous system. The ion channels responsible for the pacemaking activity are called hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. HCN channels are activated during hyperpolarization and create an inward current named I

Indexed as

campectopic dischargeshcn blockerhyperpolarization-activated cyclic nucleotide gated channels (hcn)ihinflammatory painivabradineneuropathic painneuropathypge2

Identifiers

PMID33240707
PMCPMC7682534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.