ArticlePeerJ2020
Integrated analysis of lncRNA and mRNA reveals novel insights into cashmere fineness in Tibetan cashmere goats.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Early Compound Nutritional Intervention Improves Hair Follicle Development in Northwest Xizang White Cashmere Goats: An Analysis Based on Skin Multi-Omics.Animals : an open access journal from MDPI · 2026Article
- Molecular characterization and functional insights of secondary hair follicles across the cashmere growth cycle.BMC genomics · 2026Article
- Transcriptome and proteome combined analysis of wool fiber diameter regulation mechanism.Animal bioscience · 2026Article
- Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin.Journal of animal science and technology · 2026Article
- Article
- Deciphering the molecular drivers for cashmere/pashmina fiber production in goats: a comprehensive review.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats.Frontiers in veterinary science · 2025Review
- Correlation and regression analysis of FA2H and ELOVL3 functional genes for cashmere fineness with production performance in Liaoning cashmere goat.Journal, genetic engineering & biotechnology · 2024Article
- Analysis of the Long Non-Coding and Messenger RNA Expression Profiles in the Skin Tissue of Super Merino and Small-Tailed Han Sheep.Current issues in molecular biology · 2024Article
- Hallmarks of cancer resistance.iScience · 2024Review
- Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits.BMC genomics · 2024Article
- Transcriptome meta-analysis reveals the hair genetic rules in six animal breeds and genes associated with wool fineness.Frontiers in genetics · 2024Article
- Comprehensive whole-genome resequencing unveils genetic diversity and selective signatures of the Xiangdong black goat.Frontiers in genetics · 2024Article
- Proteome Analysis of Alpine Merino Sheep Skin Reveals New Insights into the Mechanisms Involved in Regulating Wool Fiber Diameter.International journal of molecular sciences · 2023Article
- Regulation of cashmere fineness traits by noncoding RNA in Jiangnan cashmere goats.BMC genomics · 2023Article
- Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing.Animal bioscience · 2023Article
- Article
- Proteomic analysis of coarse and fine skin tissues of Liaoning cashmere goat.Functional & integrative genomics · 2022Article
- Effect of the FA2H Gene on cashmere fineness of Jiangnan cashmere goats based on transcriptome sequencing.BMC genomics · 2022Article
- Identification of the Key Genes Associated with Different Hair Types in the Inner Mongolia Cashmere Goat.Animals : an open access journal from MDPI · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tibetan cashmere goats are famous for producing the finest, softest and lightest cashmere fiber in China. The growth and development of skin are closely related to fineness and are the key factors affecting the quality of cashmere. To investigate the specific role of long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in regulating cashmere fineness of Tibetan Cashmere goats in the anagen phase, we conducted high-throughput RNA sequencing of fine-type and coarse-type skin tissues. We identified 2,059 lncRNA candidates (1,589 lncRNAs annotated, 470 lncRNAs novel), and 80 differentially expressed (DE) lncRNAs and their potential targets were predicted. We also identified 384 DE messenger RNAs (mRNAs) out of 29,119 mRNAs. Several key genes in KRT26, KRT28, KRT39, IFT88, JAK3, NOTCH2 and NOTCH3 and a series of lncRNAs, including ENSCHIT00000009853, MSTRG.16794.17, MSTRG.17532.2, were shown to be potentially important for regulating cashmere fineness. GO and KEGG enrichment analyses of DE mRNAs and DE lncRNAs targets significantly enriched in positive regulation of the canonical Wnt signaling pathway, regulation of protein processing and metabolism processes. The mRNA-mRNA and lncRNA-mRNA regulatory networks further revealed potential transcripts involved in cashmere fineness. We further validated the expression patterns of DE mRNAs and DE lncRNAs by quantitative real-time PCR (qRT-PCR), and the results were consistent with the sequencing data. This study will shed new light on selective cashmere goat breeding, and these lncRNAs and mRNAs that were found to be enriched in Capra hircus RNA database.
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