ReviewAllergy & rhinology (Providence, R.I.)
Gross Total Versus Subtotal Surgical Resection in the Management of Craniopharyngiomas.
Review in Allergy & rhinology (Providence, R.I.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Endoscopic endonasal transsphenoidal approach improves endocrine function and surgical outcome in primary craniopharyngioma resection: a systematic review and meta-analysis.World journal of surgical oncology · 2024Pooled it
- Exploring the Role of Skull Base Anatomy in Surgical Approach Selection and Endocrinological Outcomes in Craniopharyngiomas.Journal of clinical medicine · 2026Article
- Effect of Extent of Resection and Adjuvant Radiation on Recurrence of BRAF versus β-Catenin-Mutated Craniopharyngioma: A Single Institutional Case Series.Journal of neurological surgery. Part B, Skull base · 2025Article
- Revisiting the combined approach of Yaşargil for microsurgical removal of intra-extraventricular and pure intraventricular craniopharyngiomas.Acta neurochirurgica · 2025Article
- Single Center Neurosurgical Outcomes and Trends in Endoscopic Endonasal Resection of 297 Sellar/Suprasellar Tumors Stratified by Duration of Neurosurgical Career.World neurosurgery · 2024Article
- A 55-Year-Old Woman Presenting with a Second Diagnosis of Craniopharyngioma Following Diagnosis and Successful Treatment of Craniopharyngioma as a 5-Year-Old Child.The American journal of case reports · 2024Article
- Biophysical and Biological Mechanisms of Tumor Treating Fields in Glioblastoma.Journal of cancer science and clinical therapeutics · 2024Article
- Quality of life of pediatric patients with craniopharyngioma: A retrospective series from a low-middle-income country with more than 4 years follow-up.Surgical neurology international · 2024Article
- Caregiver Burden and Its Relationship to Health-Related Quality of Life in Craniopharyngioma Survivors.The Journal of clinical endocrinology and metabolism · 2023Article
- Chemotherapy in pediatric brain tumor and the challenge of the blood-brain barrier.Cancer medicine · 2023Review
- Evolution of Surgical Outcomes in Endoscopic Endonasal Resection of Craniopharyngiomas.Journal of neurological surgery. Part B, Skull base · 2023Article
- Postoperative hypothalamic-pituitary dysfunction and long-term hormone replacement in patients with childhood-onset craniopharyngioma.Frontiers in endocrinology · 2023Article
- Limited surgery and conformal photon radiation therapy for pediatric craniopharyngioma: long-term results from the RT1 protocol.Neuro-oncology · 2022Article
- Multidisciplinary Management of Craniopharyngiomas in Children: A Single Center Experience.Diagnostics (Basel, Switzerland) · 2022Article
- Whether surgical resection or biopsy makes difference in single lesion primary central nervous system lymphoma: a single center retrospective cohort study.BMC neurology · 2022Article
- Surgical outcomes of pediatric brain tumors in Sub-Saharan Africa: A systematic review.Brain & spine · 2022Review
- Giant Pediatric Supratentorial Tumor: Clinical Feature and Surgical Strategy.Frontiers in pediatrics · 2022Article
- Characteristics and overall survival in pediatric versus adult craniopharyngioma: a population-based study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniopharyngiomas (CP) are suprasellar tumors that can grow into vital nearby structures and thus cause significant visual, endocrine, and hypothalamic dysfunction. Debate persists as to the optimal treatment strategy for these benign lesions, particularly with regards to the extent of surgical resection. The goals of tumor resection are to eliminate the compressive effect of the tumor on surrounding structures and minimize recurrence. It remains unclear whether a gross total resection (GTR) or subtotal resection (STR) with adjuvant therapy confers a better prognosis. Chemotherapy and radiation therapy (RT) have been explored as both neoadjuvant and adjuvant treatments to decrease tumor burden and prevent recurrence. The objective of this paper is to review the risks and benefits of GTR versus STR, specifically with regard to risk of recurrence and postoperative morbidity. Aggregated data suggest that STR monotherapy is associated with higher rates of recurrence relative to GTR (50.6% ± 22.1% vs 20.2% ± 13.5%), while STR combined with RT leads to recurrence rates similar to GTR. However, both GTR and RT are independently associated with higher rates of comorbidities including panhypopituitarism, diabetes insipidus, and visual deficits. The treatment strategy for CPs should ultimately be tailored to each patient's individual tumor characteristics, risk, symptoms, and therapeutic goals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.