ArticleFrontiers in immunology2020
GPR183 Regulates Interferons, Autophagy, and Bacterial Growth During
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Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 18% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Immune dysregulation in tuberculosis-diabetes comorbidity: mechanistic and translational insights.Frontiers in immunology · 2026Pooled it
- Targeting the GPR183/EBI2‒oxysterol axis in tuberculosis: Immunometabolic regulation and prospects for host-directed therapy.Clinical and translational medicine · 2026Review
- GPR183 contributes to renal macrophage infiltration and fibrosis in kidney injury.American journal of physiology. Renal physiology · 2026Article
- Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes.The Journal of experimental medicine · 2026Article
- Oxysterol-mediated modulation of intestinal inflammation: insights into sex differences and GPR183 signaling.Cellular and molecular life sciences : CMLS · 2025Article
- Systems-level characterization of EGFR kinase inhibitors reveals heterogeneous effects on Mtb-macrophage interactions.bioRxiv : the preprint server for biology · 2025Article
- G-protein coupled receptor 183 (GPR183) inhibits visceral metastasis of non-small cell lung cancer.Clinical & experimental metastasis · 2025Article
- Diet-induced dyslipidemia enhances IFN-γ production in mycolic acid-specific T cells and affects mycobacterial control.Mucosal immunology · 2025Article
- Oxysterol-Induced Inflammation in Human Diseases: Strategies for Treatment with Natural Compounds and Synthetic Molecules.Molecules (Basel, Switzerland) · 2025Review
- Mitochondria-enriched hematopoietic stem cells exhibit elevated self-renewal capabilities, thriving within the context of aged bone marrow.Nature aging · 2025Article
- Altered baseline immunological state and impaired immune response to SARS-CoV-2 mRNA vaccination in lung transplant recipients.Cell reports. Medicine · 2025Article
- Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages.Microorganisms · 2025Article
- Lessons from cross-pathogen studies: understanding the metabolic rewiring of macrophages upon infection.Frontiers in cellular and infection microbiology · 2025Review
- First report on chemometrics-driven multilayered lead prioritization in addressing oxysterol-mediated overexpression of G protein-coupled receptor 183.Molecular diversity · 2024Article
- Sexual Dimorphism in the Immunometabolic Role of Gpr183 in Mice.Journal of the Endocrine Society · 2024Article
- GPCRs: emerging targets for novel T cell immune checkpoint therapy.Cancer immunology, immunotherapy : CII · 2024Review
- The Association between Dyslipidemia and Pulmonary Diseases.Journal of atherosclerosis and thrombosis · 2024Review
- Functional Analysis of Genes inIndian journal of microbiology · 2024Review
- The role of cholesterol and its oxidation products in tuberculosis pathogenesis.Immunometabolism (Cobham, Surrey) · 2024Review
- The impact ofFrontiers in immunology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 7 institutions in 4 countries.
Stacey BartlettTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Adrian Tandhyka GemiartoTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Minh Dao NgoTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Haressh SajiirTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Semira HailuTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Roma SinhaTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Cheng Xiang FooTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Léanie KleynhansDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Happy TshivhulaDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Tariq WebberDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Helle Bielefeldt-OhmannSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Nicholas P WestSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.
Andriette M HiemstraDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Candice E MacDonaldDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Liv von Voss ChristensenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Larry S SchlesingerHost-Pathogens Interactions Program, Texas Biomedical Research Institute, San Antonio, TX, United States.
Gerhard WalzlDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Mette Marie RosenkildeDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Thomas Mandrup-PoulsenDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Katharina RonacherTranslational Research Institute-Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
University of Queensland · AUStellenbosch University · ZAMater Research · AUUniversity of Copenhagen · DKSouth African Medical Research Council · ZATexas Biomedical Research Institute · USTranslational Research Institute · AU
Funding
Altered immune-endocrine axis in type 2 diabetes and tuberculosis riskR01AI116039 · NIAID · STELLENBOSCH UNIVERSITY · PI KLEYNHANS, LEANIE, RESTREPO, BLANCA I · 2015 to 2019
$1.7MNIAID NIH HHS R01 AI116039
Abstract
Oxidized cholesterols have emerged as important signaling molecules of immune function, but little is known about the role of these oxysterols during mycobacterial infections. We found that expression of the oxysterol-receptor GPR183 was reduced in blood from patients with tuberculosis (TB) and type 2 diabetes (T2D) compared to TB patients without T2D and was associated with TB disease severity on chest x-ray. GPR183 activation by 7
Indexed as
AutophagyAnimalsBacterial LoadCase-Control StudiesDiabetes Mellitus, Type 2Disease Models, AnimalFemaleHost-Pathogen InteractionsHumansInterferonsLeukocytes, MononuclearLungMaleMice, Inbred C57BLMice, KnockoutMycobacterium bovisGPR183 protein, humanGpr183 protein, mouseInterferonsReceptors, G-Protein-Coupled7α,25-dihydroxycholesterolautophagydiabetesEBI2GPR183host-direct therapiesMycobacterium tuberculosisoxysterols
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.